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Boosted production of antibodies which neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following mRNA vaccination - a case study

Ravlo, Erlend ; Ianevski, Aleksandr ; Starheim, Eirin ; Wang, Wei ; Ji, Ping ; Lysvand, Hilde ; Smura, Teemu ; Kivi, Gaily ; Voolaid, Maia-Liisa and Plaan, Kati , et al. (2023) In International Journal of Infectious Diseases 137. p.75-78
Abstract

Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8... (More)

Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8 was structurally similarly to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effect to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. -.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Infectious Diseases
volume
137
pages
75 - 78
publisher
Elsevier
external identifiers
  • scopus:85178649449
  • pmid:37852599
ISSN
1878-3511
DOI
10.1016/j.ijid.2023.10.011
language
English
LU publication?
yes
additional info
Copyright © 2023. Published by Elsevier Ltd.
id
eb8c0341-cabe-4400-804f-6c10528b84b8
date added to LUP
2023-10-19 17:03:25
date last changed
2024-04-23 11:11:43
@article{eb8c0341-cabe-4400-804f-6c10528b84b8,
  abstract     = {{<p>Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding S protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J and partially 21K strains. 100F8 was structurally similarly to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effect to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. -.</p>}},
  author       = {{Ravlo, Erlend and Ianevski, Aleksandr and Starheim, Eirin and Wang, Wei and Ji, Ping and Lysvand, Hilde and Smura, Teemu and Kivi, Gaily and Voolaid, Maia-Liisa and Plaan, Kati and Ustav, Mart and Zusinaite, Eva and Tenson, Tanel and Kurg, Reet and Oksenych, Valentyn and Walstad, Kirsti and Nordbø, Svein Arne and Kaarbø, Mari and Ernits, Karin and Bjørås, Magnar and Kainov, Denis E and Høysæter Fenstad, Mona}},
  issn         = {{1878-3511}},
  language     = {{eng}},
  month        = {{10}},
  pages        = {{75--78}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Infectious Diseases}},
  title        = {{Boosted production of antibodies which neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following mRNA vaccination - a case study}},
  url          = {{http://dx.doi.org/10.1016/j.ijid.2023.10.011}},
  doi          = {{10.1016/j.ijid.2023.10.011}},
  volume       = {{137}},
  year         = {{2023}},
}