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Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment

, ; Gonzales, Mitzi M.; Insel, Philip S. LU ; Nelson, Craig; Tosun, Duygu; Schöll, Michael LU ; Mattsson, Niklas LU ; Sacuiu, Simona; Bickford, David and Weiner, Michael W., et al. (2018) In International Journal of Geriatric Psychiatry 33(10). p.1305-1311
Abstract

Objectives: To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Methods: Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ1–42), total tau (t-tau), and phosphorylated tau (p-tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non-SSD group N = 158) of depressive symptoms across timepoints. CSF biomarker and cognitive performance were evaluated with linear regression models... (More)

Objectives: To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Methods: Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ1–42), total tau (t-tau), and phosphorylated tau (p-tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non-SSD group N = 158) of depressive symptoms across timepoints. CSF biomarker and cognitive performance were evaluated with linear regression models adjusting for age, education, gender, APOE genotype, global cognitive status, and SSD group. Results: As compared to the non-SSD group, the SSD group displayed lower CSF Aβ1–42 levels (β = −24.293, S.E. = 6.345, P < 0.001). No group differences were observed for CSF t-tau (P = 0.497) or p-tau levels (P = 0.392). Lower CSF Aβ1–42 levels were associated with poorer performance on learning (β = 0.041, S.E. = 0.018, P = 0.021) and memory (β = −0.012, S.E. = 0.005, P = 0.031) measures, whereas higher CSF t-tau levels were associated with poorer performance on measures of global cognition (β = 0.022, S.E = 0.008, P = 0.007) and language (β = −0.010, S.E = 0.004, P = 0.019). SSD was independently associated with diminished global cognition, learning and memory, language, and executive function performance over and above the effects of CSF biomarkers (all P < 0.05). Conclusions: MCI participants with SSD displayed diminished CSF Aβ1–42 levels but did not differ from non-SSD controls in CSF tau levels. Additionally, CSF biomarkers and SSD independently accounted for variance in cognitive performance, suggesting that these factors may uniquely confer cognitive risk in MCI.

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published
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keywords
amyloid beta, CSF biomarkers, depression, mild cognitive impairment, tau
in
International Journal of Geriatric Psychiatry
volume
33
issue
10
pages
7 pages
publisher
John Wiley and Sons Ltd
external identifiers
  • scopus:85053605498
ISSN
0885-6230
DOI
10.1002/gps.4926
language
English
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yes
id
eb9733b8-f3d0-4be8-836a-13de7747867e
date added to LUP
2018-10-09 14:46:01
date last changed
2019-02-20 11:30:39
@article{eb9733b8-f3d0-4be8-836a-13de7747867e,
  abstract     = {<p>Objectives: To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Methods: Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ<sub>1–42</sub>), total tau (t-tau), and phosphorylated tau (p-tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non-SSD group N = 158) of depressive symptoms across timepoints. CSF biomarker and cognitive performance were evaluated with linear regression models adjusting for age, education, gender, APOE genotype, global cognitive status, and SSD group. Results: As compared to the non-SSD group, the SSD group displayed lower CSF Aβ<sub>1–42</sub> levels (β = −24.293, S.E. = 6.345, P &lt; 0.001). No group differences were observed for CSF t-tau (P = 0.497) or p-tau levels (P = 0.392). Lower CSF Aβ<sub>1–42</sub> levels were associated with poorer performance on learning (β = 0.041, S.E. = 0.018, P = 0.021) and memory (β = −0.012, S.E. = 0.005, P = 0.031) measures, whereas higher CSF t-tau levels were associated with poorer performance on measures of global cognition (β = 0.022, S.E = 0.008, P = 0.007) and language (β = −0.010, S.E = 0.004, P = 0.019). SSD was independently associated with diminished global cognition, learning and memory, language, and executive function performance over and above the effects of CSF biomarkers (all P &lt; 0.05). Conclusions: MCI participants with SSD displayed diminished CSF Aβ<sub>1–42</sub> levels but did not differ from non-SSD controls in CSF tau levels. Additionally, CSF biomarkers and SSD independently accounted for variance in cognitive performance, suggesting that these factors may uniquely confer cognitive risk in MCI.</p>},
  author       = {,  and Gonzales, Mitzi M. and Insel, Philip S. and Nelson, Craig and Tosun, Duygu and Schöll, Michael and Mattsson, Niklas and Sacuiu, Simona and Bickford, David and Weiner, Michael W. and Mackin, R. Scott},
  issn         = {0885-6230},
  keyword      = {amyloid beta,CSF biomarkers,depression,mild cognitive impairment,tau},
  language     = {eng},
  number       = {10},
  pages        = {1305--1311},
  publisher    = {John Wiley and Sons Ltd},
  series       = {International Journal of Geriatric Psychiatry},
  title        = {Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment},
  url          = {http://dx.doi.org/10.1002/gps.4926},
  volume       = {33},
  year         = {2018},
}