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Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts

Yates, Max; Watts, Richard; Bajema, Ingeborg; Cid, Maria C.; Crestani, Bruno; Hauser, Thomas; Hellmich, Bernhard; Holle, Julia; Laudien, Martin and Little, Mark A., et al. (2017) In RMD Open 3(1).
Abstract

The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted on by members of a learned society. This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis. In addition to the task force, a learned society (European Vasculitis Society - EUVAS) was invited, through online survey, to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations. The survey took place in June... (More)

The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted on by members of a learned society. This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis. In addition to the task force, a learned society (European Vasculitis Society - EUVAS) was invited, through online survey, to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations. The survey took place in June 2015. Of the 158 EUVAS members surveyed, there were 88 responses (55.7%). There was a large degree of agreement in the voting patterns between EUVAS survey participants and task force members. Notable exceptions were lower grades for the recommendation of the use of rituximab for remission induction in patients with eosinophilic granulomatosis with polyangiitis and for methotrexate and mycophenolate mofetil as remission maintenance agents in patients with granulomatosis with polyangiitis/microscopic polyangiitis by EUVAS members. These results are encouraging and suggest that the voting patterns of the task force are representative of the wider vasculitis community. We recommend future recommendations adopt this approach for data/expert-based treatment guidelines, especially for multisystem diseases.

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ANCA-associated vasculitis, Recommendations, Survey
in
RMD Open
volume
3
issue
1
publisher
BMJ Publishing Group
external identifiers
  • scopus:85020885130
ISSN
2056-5933
DOI
10.1136/rmdopen-2017-000449
language
English
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yes
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ebbb1ef4-aade-4d1b-abbb-ba0aa8c24923
date added to LUP
2017-08-17 12:18:10
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2018-01-07 12:15:06
@article{ebbb1ef4-aade-4d1b-abbb-ba0aa8c24923,
  abstract     = {<p>The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted on by members of a learned society. This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis. In addition to the task force, a learned society (European Vasculitis Society - EUVAS) was invited, through online survey, to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations. The survey took place in June 2015. Of the 158 EUVAS members surveyed, there were 88 responses (55.7%). There was a large degree of agreement in the voting patterns between EUVAS survey participants and task force members. Notable exceptions were lower grades for the recommendation of the use of rituximab for remission induction in patients with eosinophilic granulomatosis with polyangiitis and for methotrexate and mycophenolate mofetil as remission maintenance agents in patients with granulomatosis with polyangiitis/microscopic polyangiitis by EUVAS members. These results are encouraging and suggest that the voting patterns of the task force are representative of the wider vasculitis community. We recommend future recommendations adopt this approach for data/expert-based treatment guidelines, especially for multisystem diseases.</p>},
  articleno    = {e000449},
  author       = {Yates, Max and Watts, Richard and Bajema, Ingeborg and Cid, Maria C. and Crestani, Bruno and Hauser, Thomas and Hellmich, Bernhard and Holle, Julia and Laudien, Martin and Little, Mark A. and Luqmani, Raashid Ahmed and Mahr, Alfred and Merkel, Peter A and Mills, John and Mooney, Janice and Segelmark, Mårten and Tesar, Vladimir and Westman, Kerstin W.A. and Vaglio, Augusto and Yalçlnda, Nilüfer and Jayne, David Rw and Mukhtyar, Chetan},
  issn         = {2056-5933},
  keyword      = {ANCA-associated vasculitis,Recommendations,Survey},
  language     = {eng},
  month        = {06},
  number       = {1},
  publisher    = {BMJ Publishing Group},
  series       = {RMD Open},
  title        = {Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts},
  url          = {http://dx.doi.org/10.1136/rmdopen-2017-000449},
  volume       = {3},
  year         = {2017},
}