Body size and risk of atrial fibrillation : A cohort study of 1.1 million young men
(2018) In Journal of Internal Medicine 283(4). p.346-355- Abstract
Background: Whilst tall stature has been related to lower risk of vascular disease, it has been proposed as a risk factor for atrial fibrillation. Little is known about other anthropometric measures and their joint effects on risk of atrial fibrillation. Objectives: We aim to investigate associations and potential joint effects of height, weight, body surface area (BSA) and body mass index (BMI) with risk of atrial fibrillation. Methods: In a cohort covering 1 153 151 18-year-old men participating in the Swedish military conscription (1972-1995), Cox regression was used to investigate associations of height, weight, BSA and BMI with risk of atrial fibrillation. Results: During a median of 26.3 years of follow-up, higher height was... (More)
Background: Whilst tall stature has been related to lower risk of vascular disease, it has been proposed as a risk factor for atrial fibrillation. Little is known about other anthropometric measures and their joint effects on risk of atrial fibrillation. Objectives: We aim to investigate associations and potential joint effects of height, weight, body surface area (BSA) and body mass index (BMI) with risk of atrial fibrillation. Methods: In a cohort covering 1 153 151 18-year-old men participating in the Swedish military conscription (1972-1995), Cox regression was used to investigate associations of height, weight, BSA and BMI with risk of atrial fibrillation. Results: During a median of 26.3 years of follow-up, higher height was associated with higher risk of atrial fibrillation (hazard ratio [HR] 2.80; 95% CI 2.63-2.98; for 5th vs. 1st quintile) and so was larger BSA (HR 3.05; 95% CI 2.82-3.28; for 5th vs. 1st quintile). Higher weight and BMI were to a lesser extent associated with risk of atrial fibrillation (BMI: 1.42; 95% CI 1.33-1.52, for 5th vs. 1st quintile). We found a multiplicative joint effect of height and weight. Adjusting for muscle strength, exercise capacity and diseases related to atrial fibrillation attenuated these measures. Conclusions: Higher height and weight are strongly associated with higher risk of atrial fibrillation. These associations are multiplicative and independent of each other and are summarized in a strong association of body surface area with risk of atrial fibrillation. The mechanisms remain unknown but may involve increased atrial volume load with larger body size.
(Less)
- author
- Andersen, K. ; Rasmussen, F. LU ; Neovius, M. ; Tynelius, P. and Sundström, J.
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atrial fibrillation, Body mass Index, Body surface area, Height, Weight
- in
- Journal of Internal Medicine
- volume
- 283
- issue
- 4
- pages
- 346 - 355
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:29178512
- scopus:85038937679
- ISSN
- 0954-6820
- DOI
- 10.1111/joim.12717
- language
- English
- LU publication?
- yes
- id
- ebccfbf6-0184-4356-b0c2-f7a11c5a1213
- date added to LUP
- 2018-01-23 13:16:29
- date last changed
- 2023-03-14 04:29:00
@article{ebccfbf6-0184-4356-b0c2-f7a11c5a1213,
abstract = {{<p>Background: Whilst tall stature has been related to lower risk of vascular disease, it has been proposed as a risk factor for atrial fibrillation. Little is known about other anthropometric measures and their joint effects on risk of atrial fibrillation. Objectives: We aim to investigate associations and potential joint effects of height, weight, body surface area (BSA) and body mass index (BMI) with risk of atrial fibrillation. Methods: In a cohort covering 1 153 151 18-year-old men participating in the Swedish military conscription (1972-1995), Cox regression was used to investigate associations of height, weight, BSA and BMI with risk of atrial fibrillation. Results: During a median of 26.3 years of follow-up, higher height was associated with higher risk of atrial fibrillation (hazard ratio [HR] 2.80; 95% CI 2.63-2.98; for 5th vs. 1st quintile) and so was larger BSA (HR 3.05; 95% CI 2.82-3.28; for 5th vs. 1st quintile). Higher weight and BMI were to a lesser extent associated with risk of atrial fibrillation (BMI: 1.42; 95% CI 1.33-1.52, for 5th vs. 1st quintile). We found a multiplicative joint effect of height and weight. Adjusting for muscle strength, exercise capacity and diseases related to atrial fibrillation attenuated these measures. Conclusions: Higher height and weight are strongly associated with higher risk of atrial fibrillation. These associations are multiplicative and independent of each other and are summarized in a strong association of body surface area with risk of atrial fibrillation. The mechanisms remain unknown but may involve increased atrial volume load with larger body size.</p>}},
author = {{Andersen, K. and Rasmussen, F. and Neovius, M. and Tynelius, P. and Sundström, J.}},
issn = {{0954-6820}},
keywords = {{Atrial fibrillation; Body mass Index; Body surface area; Height; Weight}},
language = {{eng}},
number = {{4}},
pages = {{346--355}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Body size and risk of atrial fibrillation : A cohort study of 1.1 million young men}},
url = {{http://dx.doi.org/10.1111/joim.12717}},
doi = {{10.1111/joim.12717}},
volume = {{283}},
year = {{2018}},
}