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Lack of analgesic effects of transcranial pulsed electromagnetic field stimulation in neuropathic pain patients : A randomized double-blind crossover trial

Geraets, Chris N.W. LU ; van Beilen, Marije ; van Dijk, Mirjan ; Kleijer, Hidde ; Köhne, Charlotte ; van der Hoeven, Johannes H. ; Groen, Gerbrand J. ; Ćurčić-Blake, Branislava ; Schoevers, Robert A. and Maurits, Natasha M. , et al. (2019) In Neuroscience Letters 699. p.212-216
Abstract

Background: Neuromodulation is nowadays investigated as a promising method for pain relief. Research indicates that a single 30-minute stimulation with transcranial pulsed electromagnetic fields (tPEMF) can induce analgesic effects. However, it is unknown whether tPEMF can induce analgesia in neuropathic pain patients. Objective: To evaluate the effect of tPEMF on spontaneous pain and heat pain in neuropathic pain patients. Methods: This study had a randomized double-blind crossover design. Twenty neuropathic pain patients received 30-minutes of tPEMF and 30-minutes sham stimulation. Primary outcomes were pain intensity, pain aversion and heat pain. Secondary outcomes included affect, cognition, and motor function, to investigate... (More)

Background: Neuromodulation is nowadays investigated as a promising method for pain relief. Research indicates that a single 30-minute stimulation with transcranial pulsed electromagnetic fields (tPEMF) can induce analgesic effects. However, it is unknown whether tPEMF can induce analgesia in neuropathic pain patients. Objective: To evaluate the effect of tPEMF on spontaneous pain and heat pain in neuropathic pain patients. Methods: This study had a randomized double-blind crossover design. Twenty neuropathic pain patients received 30-minutes of tPEMF and 30-minutes sham stimulation. Primary outcomes were pain intensity, pain aversion and heat pain. Secondary outcomes included affect, cognition, and motor function, to investigate safety, tolerability and putative working mechanisms of tPEMF. Outcomes were assessed before, during and after stimulation. Results: No differences in analgesic effects between tPEMF and sham stimulation were found for pain intensity, pain aversion or heat pain. No differences between tPEMF and sham stimulation were observed for affect, motor, and cognitive outcomes. Conclusion: A single 30-minute tPEMF stimulation did not induce analgesic effects in neuropathic pain patients, compared to sham. Further study is needed to determine whether prolonged stimulation is necessary for analgesic effects.

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publishing date
type
Contribution to journal
publication status
published
keywords
Complex neural pulse (CNP), Extremely low frequency (ELF), Neuromodulation, Neuropathic pain, Pulsed electromagnetic fields (PEMF), Transcranial magnetic stimulation
in
Neuroscience Letters
volume
699
pages
212 - 216
publisher
Elsevier
external identifiers
  • scopus:85061569711
ISSN
0304-3940
DOI
10.1016/j.neulet.2019.01.051
language
English
LU publication?
no
additional info
Publisher Copyright: © 2019 The Author(s)
id
ebe1a550-e4bb-4476-80ad-845224074564
date added to LUP
2024-10-21 10:36:11
date last changed
2024-10-22 09:24:46
@article{ebe1a550-e4bb-4476-80ad-845224074564,
  abstract     = {{<p>Background: Neuromodulation is nowadays investigated as a promising method for pain relief. Research indicates that a single 30-minute stimulation with transcranial pulsed electromagnetic fields (tPEMF) can induce analgesic effects. However, it is unknown whether tPEMF can induce analgesia in neuropathic pain patients. Objective: To evaluate the effect of tPEMF on spontaneous pain and heat pain in neuropathic pain patients. Methods: This study had a randomized double-blind crossover design. Twenty neuropathic pain patients received 30-minutes of tPEMF and 30-minutes sham stimulation. Primary outcomes were pain intensity, pain aversion and heat pain. Secondary outcomes included affect, cognition, and motor function, to investigate safety, tolerability and putative working mechanisms of tPEMF. Outcomes were assessed before, during and after stimulation. Results: No differences in analgesic effects between tPEMF and sham stimulation were found for pain intensity, pain aversion or heat pain. No differences between tPEMF and sham stimulation were observed for affect, motor, and cognitive outcomes. Conclusion: A single 30-minute tPEMF stimulation did not induce analgesic effects in neuropathic pain patients, compared to sham. Further study is needed to determine whether prolonged stimulation is necessary for analgesic effects.</p>}},
  author       = {{Geraets, Chris N.W. and van Beilen, Marije and van Dijk, Mirjan and Kleijer, Hidde and Köhne, Charlotte and van der Hoeven, Johannes H. and Groen, Gerbrand J. and Ćurčić-Blake, Branislava and Schoevers, Robert A. and Maurits, Natasha M. and Kortekaas, Rudie}},
  issn         = {{0304-3940}},
  keywords     = {{Complex neural pulse (CNP); Extremely low frequency (ELF); Neuromodulation; Neuropathic pain; Pulsed electromagnetic fields (PEMF); Transcranial magnetic stimulation}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{212--216}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Lack of analgesic effects of transcranial pulsed electromagnetic field stimulation in neuropathic pain patients : A randomized double-blind crossover trial}},
  url          = {{http://dx.doi.org/10.1016/j.neulet.2019.01.051}},
  doi          = {{10.1016/j.neulet.2019.01.051}},
  volume       = {{699}},
  year         = {{2019}},
}