The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity
(1986) In Biochemical and Biophysical Research Communications 139(3). p.1239-1242- Abstract
- The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1296148
- author
- Gullberg, Urban LU ; Widegren, Bengt LU ; Arnason, Ulfur LU ; Egesten, Arne LU and Olsson, Inge LU
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 139
- issue
- 3
- pages
- 1239 - 1242
- publisher
- Elsevier
- external identifiers
-
- scopus:0023019292
- language
- English
- LU publication?
- yes
- id
- ebe33d6c-b30e-4264-b66c-313971df1f28 (old id 1296148)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed?term=3768000
- date added to LUP
- 2016-04-04 13:29:04
- date last changed
- 2021-10-03 03:22:28
@article{ebe33d6c-b30e-4264-b66c-313971df1f28, abstract = {{The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.}}, author = {{Gullberg, Urban and Widegren, Bengt and Arnason, Ulfur and Egesten, Arne and Olsson, Inge}}, language = {{eng}}, number = {{3}}, pages = {{1239--1242}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed?term=3768000}}, volume = {{139}}, year = {{1986}}, }