Differential regulation of α and β chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S
(1994) In Blood 84(3). p.815-822- Abstract
- Regulation of C4b-binding protein (C4BP) isoforms during acute phase and its relationship to the plasma concentration of free protein S was elucidated. An assay for β chain containing C4BP (C4BPβ+) was developed and the concentrations of total C4BP, C4BPβ+, total, free, and bound protein S were measured in patients with acute-phase response. Even though total C4BP was increased to 162% (mean value) of controls, the corresponding value of C4BPβ+ was only 122%. In the acute-phase group, total protein S was increased to the same extent as C4BPβ+ (mean value of 124%), whereas free protein S was not decreased. In controls, total and bound protein S correlated with total C4BP and C4BPβ+. However, in the acute-phase group, the correlation between... (More)
- Regulation of C4b-binding protein (C4BP) isoforms during acute phase and its relationship to the plasma concentration of free protein S was elucidated. An assay for β chain containing C4BP (C4BPβ+) was developed and the concentrations of total C4BP, C4BPβ+, total, free, and bound protein S were measured in patients with acute-phase response. Even though total C4BP was increased to 162% (mean value) of controls, the corresponding value of C4BPβ+ was only 122%. In the acute-phase group, total protein S was increased to the same extent as C4BPβ+ (mean value of 124%), whereas free protein S was not decreased. In controls, total and bound protein S correlated with total C4BP and C4BPβ+. However, in the acute-phase group, the correlation between bound protein S and total C4BP was lost, although the correlation between C4BPβ+ and protein S remained. The present results suggest stable levels of free protein S during acute phase to be the result of differential regulation of C4BP α- and β-chain expression, and the concentration of free protein S to be the resulting molar excess of protein S over C4BPβ+. This mechanism ensures functional levels of free anticoagulant protein S despite high levels of C4BP. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ec14e5d6-6fe2-4497-af6e-e1a32fd4101c
- author
- Garcia de Frutos, Pablo LU ; Alim, R.I.M. ; Härdig, Ylva ; Zöller, Bengt LU and Dahlbäck, Björn LU
- organization
- publishing date
- 1994-11-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- binding protein, complement component C4b, protein S, acute phase response, alpha chain, article, beta chain, human, plasma, priority journal, protein blood level, protein determination, serum
- in
- Blood
- volume
- 84
- issue
- 3
- pages
- 8 pages
- publisher
- American Society of Hematology
- ISSN
- 1528-0020
- language
- English
- LU publication?
- yes
- id
- ec14e5d6-6fe2-4497-af6e-e1a32fd4101c
- date added to LUP
- 2017-11-02 11:26:04
- date last changed
- 2021-07-30 04:04:39
@article{ec14e5d6-6fe2-4497-af6e-e1a32fd4101c, abstract = {{Regulation of C4b-binding protein (C4BP) isoforms during acute phase and its relationship to the plasma concentration of free protein S was elucidated. An assay for β chain containing C4BP (C4BPβ+) was developed and the concentrations of total C4BP, C4BPβ+, total, free, and bound protein S were measured in patients with acute-phase response. Even though total C4BP was increased to 162% (mean value) of controls, the corresponding value of C4BPβ+ was only 122%. In the acute-phase group, total protein S was increased to the same extent as C4BPβ+ (mean value of 124%), whereas free protein S was not decreased. In controls, total and bound protein S correlated with total C4BP and C4BPβ+. However, in the acute-phase group, the correlation between bound protein S and total C4BP was lost, although the correlation between C4BPβ+ and protein S remained. The present results suggest stable levels of free protein S during acute phase to be the result of differential regulation of C4BP α- and β-chain expression, and the concentration of free protein S to be the resulting molar excess of protein S over C4BPβ+. This mechanism ensures functional levels of free anticoagulant protein S despite high levels of C4BP.}}, author = {{Garcia de Frutos, Pablo and Alim, R.I.M. and Härdig, Ylva and Zöller, Bengt and Dahlbäck, Björn}}, issn = {{1528-0020}}, keywords = {{binding protein; complement component C4b; protein S; acute phase response; alpha chain; article; beta chain; human; plasma; priority journal; protein blood level; protein determination; serum}}, language = {{eng}}, month = {{11}}, number = {{3}}, pages = {{815--822}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Differential regulation of α and β chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S}}, volume = {{84}}, year = {{1994}}, }