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Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache

Rapoport, Alan M. and Edvinsson, Lars LU (2019) In Neurological Sciences 40(S1). p.75-80
Abstract

Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes more frequent, shorter, and even more intense pain than migraine. The pain usually comes in cycles and is associated with ipsilateral autonomic features and associated with irritability and inability to stay still. It affects less than 0.1% of the population and is slightly more prevalent in men than women. Although we have some acute care and... (More)

Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes more frequent, shorter, and even more intense pain than migraine. The pain usually comes in cycles and is associated with ipsilateral autonomic features and associated with irritability and inability to stay still. It affects less than 0.1% of the population and is slightly more prevalent in men than women. Although we have some acute care and preventive medications for both types of headache, no treatment is optimal for each patient and some will not respond well or have significant adverse events to existing therapies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CGRP, Cluster headache therapy, Headache devices, Migraine therapy, Monoclonal antibodies to calcitonin gene–related peptide or its receptor, Pathophysiology of migraine
in
Neurological Sciences
volume
40
issue
S1
pages
75 - 80
publisher
Springer
external identifiers
  • pmid:30906962
  • scopus:85064158041
ISSN
1590-1874
DOI
10.1007/s10072-019-03828-0
language
English
LU publication?
yes
id
ec2a293f-2a6c-4651-94f0-b37f3ef75530
date added to LUP
2019-05-08 12:45:09
date last changed
2020-07-08 04:50:27
@article{ec2a293f-2a6c-4651-94f0-b37f3ef75530,
  abstract     = {<p>Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes more frequent, shorter, and even more intense pain than migraine. The pain usually comes in cycles and is associated with ipsilateral autonomic features and associated with irritability and inability to stay still. It affects less than 0.1% of the population and is slightly more prevalent in men than women. Although we have some acute care and preventive medications for both types of headache, no treatment is optimal for each patient and some will not respond well or have significant adverse events to existing therapies.</p>},
  author       = {Rapoport, Alan M. and Edvinsson, Lars},
  issn         = {1590-1874},
  language     = {eng},
  number       = {S1},
  pages        = {75--80},
  publisher    = {Springer},
  series       = {Neurological Sciences},
  title        = {Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache},
  url          = {http://dx.doi.org/10.1007/s10072-019-03828-0},
  doi          = {10.1007/s10072-019-03828-0},
  volume       = {40},
  year         = {2019},
}