Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Laser Doppler flowmetry evaluation of skin microvascular endothelial function in patients with metabolic syndrome

Girkantaite, Zivile ; Laucyte-Cibulskiene, Agne LU orcid ; Ryliskyte, Ligita ; Juceviciene, Agne and Badariene, Jolita (2022) In Microvascular Research 142.
Abstract

Background: Metabolic syndrome (MetS) is associated with high cardiovascular morbidity and mortality, and endothelial dysfunction is an early pathogenetic event in the MetS. Lifestyle changes and pharmacological intervention might partly restore endothelial function in MetS. Whereas an optimal non-invasive test for endothelial dysfunction is still being sought, the aim of this study was to assess the relationship between changes in skin microvascular endothelial function, detected by Laser Doppler flowmetry, and cardiovascular risk factors (CVRFs) of patients with MetS. Design and methods: 3081 patients (1865 women and 1216 men, mean age 53 ± 6 years) with MetS were enrolled in the study, which was conducted during the period of... (More)

Background: Metabolic syndrome (MetS) is associated with high cardiovascular morbidity and mortality, and endothelial dysfunction is an early pathogenetic event in the MetS. Lifestyle changes and pharmacological intervention might partly restore endothelial function in MetS. Whereas an optimal non-invasive test for endothelial dysfunction is still being sought, the aim of this study was to assess the relationship between changes in skin microvascular endothelial function, detected by Laser Doppler flowmetry, and cardiovascular risk factors (CVRFs) of patients with MetS. Design and methods: 3081 patients (1865 women and 1216 men, mean age 53 ± 6 years) with MetS were enrolled in the study, which was conducted during the period of 2010–2014 at Vilnius University Hospital Santaros Klinikos. Skin microvascular endothelial function was evaluated using the Laser Doppler flowmetry in combination with the post-occlusive reactive hyperaemia test. The percentage change of flow from peak to the rest flow (PF-RF) was calculated and used as the main measure of endothelial function. Results: The study showed that decrease in flow-mediated dilatation reflected by PF-RF was associated with increased triglycerides (p = 0.002), male sex (p < 0.001), and diabetes (p = 0.002). Patients with quite a few CVRFs (body mass index ≥25 kg/m2, smoking, diabetes, arterial hypertension, a positive history of dyslipidaemia) had significantly lower PF-RF score than patients only with one of these risk factors (p < 0.001). Conclusions: Changes in skin microvascular endothelial function are significantly associated with most CVRFs and depend on the number of CVRFs.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular risk factors, Laser doppler flowmetry, Metabolic syndrome, Skin microvascular endothelial function
in
Microvascular Research
volume
142
article number
104373
publisher
Academic Press
external identifiers
  • pmid:35513175
  • scopus:85129698081
ISSN
0026-2862
DOI
10.1016/j.mvr.2022.104373
language
English
LU publication?
yes
id
ec3b1493-5801-450f-9aa1-4c4de38bc59b
date added to LUP
2022-12-28 08:45:07
date last changed
2024-04-04 17:04:23
@article{ec3b1493-5801-450f-9aa1-4c4de38bc59b,
  abstract     = {{<p>Background: Metabolic syndrome (MetS) is associated with high cardiovascular morbidity and mortality, and endothelial dysfunction is an early pathogenetic event in the MetS. Lifestyle changes and pharmacological intervention might partly restore endothelial function in MetS. Whereas an optimal non-invasive test for endothelial dysfunction is still being sought, the aim of this study was to assess the relationship between changes in skin microvascular endothelial function, detected by Laser Doppler flowmetry, and cardiovascular risk factors (CVRFs) of patients with MetS. Design and methods: 3081 patients (1865 women and 1216 men, mean age 53 ± 6 years) with MetS were enrolled in the study, which was conducted during the period of 2010–2014 at Vilnius University Hospital Santaros Klinikos. Skin microvascular endothelial function was evaluated using the Laser Doppler flowmetry in combination with the post-occlusive reactive hyperaemia test. The percentage change of flow from peak to the rest flow (PF-RF) was calculated and used as the main measure of endothelial function. Results: The study showed that decrease in flow-mediated dilatation reflected by PF-RF was associated with increased triglycerides (p = 0.002), male sex (p &lt; 0.001), and diabetes (p = 0.002). Patients with quite a few CVRFs (body mass index ≥25 kg/m<sup>2</sup>, smoking, diabetes, arterial hypertension, a positive history of dyslipidaemia) had significantly lower PF-RF score than patients only with one of these risk factors (p &lt; 0.001). Conclusions: Changes in skin microvascular endothelial function are significantly associated with most CVRFs and depend on the number of CVRFs.</p>}},
  author       = {{Girkantaite, Zivile and Laucyte-Cibulskiene, Agne and Ryliskyte, Ligita and Juceviciene, Agne and Badariene, Jolita}},
  issn         = {{0026-2862}},
  keywords     = {{Cardiovascular risk factors; Laser doppler flowmetry; Metabolic syndrome; Skin microvascular endothelial function}},
  language     = {{eng}},
  publisher    = {{Academic Press}},
  series       = {{Microvascular Research}},
  title        = {{Laser Doppler flowmetry evaluation of skin microvascular endothelial function in patients with metabolic syndrome}},
  url          = {{http://dx.doi.org/10.1016/j.mvr.2022.104373}},
  doi          = {{10.1016/j.mvr.2022.104373}},
  volume       = {{142}},
  year         = {{2022}},
}