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Longitudinal changes of macular curvature in patients with retinitis pigmentosa

Meinert, Monika LU ; Ueno, Shinji ; Komori, Shiori ; Koyanagi, Yoshito ; Sayo, Akira ; Andreasson, Sten LU ; Kominami, Taro ; Ito, Yasuki and Terasaki, Hiroko (2020) In Translational Vision Science and Technology 9(10).
Abstract

Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width,... (More)

Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width, were assessed. Results: The MMCI decreased significantly in the vertical OCT images, from –15.47 × 10−5 μm−1 to –16.36 × 10−5 μm−1 (P = 0.008) during the mean observation period of 3.4 ± 1.4 years (mean ± SD). This indicated that the macular shape became more concave. The change to a steeper shape was more prominent in eyes with less photoreceptor degeneration and for which the EZ width was preserved at >2000 μm. In three eyes, the MMCI increased markedly by >5 × 10−5 μm−1, and this was accompanied by absorption of the macular edema. Conclusions: The macular curvature in RP eyes becomes more concave in eyes with preserved EZ width. Translational Relevance: Longitudinal changes of the macular curvature in RP should be considered in future therapies, such as the implantation of the retinal prosthesis.

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; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ellipsoid zone, Macular curvature, Retinal photoreceptor layer, Retinitis pigmentosa, Spectral domain optical coherence
in
Translational Vision Science and Technology
volume
9
issue
10
article number
11
pages
8 pages
publisher
Association for Research in Vision and Ophthalmology Inc.
external identifiers
  • scopus:85090634975
  • pmid:32974083
ISSN
2164-2591
DOI
10.1167/tvst.9.10.11
language
English
LU publication?
yes
id
ec45c542-477b-4042-b88d-34a645d93f06
date added to LUP
2020-10-02 15:29:59
date last changed
2021-01-06 05:57:37
@article{ec45c542-477b-4042-b88d-34a645d93f06,
  abstract     = {<p>Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width, were assessed. Results: The MMCI decreased significantly in the vertical OCT images, from –15.47 × 10<sup>−5</sup> μm<sup>−1</sup> to –16.36 × 10<sup>−5</sup> μm<sup>−1</sup> (P = 0.008) during the mean observation period of 3.4 ± 1.4 years (mean ± SD). This indicated that the macular shape became more concave. The change to a steeper shape was more prominent in eyes with less photoreceptor degeneration and for which the EZ width was preserved at &gt;2000 μm. In three eyes, the MMCI increased markedly by &gt;5 × 10<sup>−5</sup> μm<sup>−1</sup>, and this was accompanied by absorption of the macular edema. Conclusions: The macular curvature in RP eyes becomes more concave in eyes with preserved EZ width. Translational Relevance: Longitudinal changes of the macular curvature in RP should be considered in future therapies, such as the implantation of the retinal prosthesis.</p>},
  author       = {Meinert, Monika and Ueno, Shinji and Komori, Shiori and Koyanagi, Yoshito and Sayo, Akira and Andreasson, Sten and Kominami, Taro and Ito, Yasuki and Terasaki, Hiroko},
  issn         = {2164-2591},
  language     = {eng},
  number       = {10},
  publisher    = {Association for Research in Vision and Ophthalmology Inc.},
  series       = {Translational Vision Science and Technology},
  title        = {Longitudinal changes of macular curvature in patients with retinitis pigmentosa},
  url          = {http://dx.doi.org/10.1167/tvst.9.10.11},
  doi          = {10.1167/tvst.9.10.11},
  volume       = {9},
  year         = {2020},
}