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Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer : A signature step hinting towards clinical perfection

Tuli, Hardeep Singh ; Garg, Vivek Kumar ; Bhushan, Sakshi ; Uttam, Vivek ; Sharma, Uttam ; Jain, Aklank ; Sak, Katrin ; Yadav, Vikas LU ; Lorenzo, Jose M. and Dhama, Kuldeep , et al. (2023) In Translational Oncology 27.
Abstract

Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and... (More)

Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-proliferation, Apoptosis, Cancer, Flavonoids, MicroRNAs, Synergism
in
Translational Oncology
volume
27
article number
101596
publisher
Neoplasia Press
external identifiers
  • pmid:36473401
  • scopus:85143309843
ISSN
1936-5233
DOI
10.1016/j.tranon.2022.101596
language
English
LU publication?
yes
id
ec648e49-fb86-4ce1-a50a-5dd79aec0490
date added to LUP
2023-02-07 15:24:19
date last changed
2024-04-18 19:29:08
@article{ec648e49-fb86-4ce1-a50a-5dd79aec0490,
  abstract     = {{<p>Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future.</p>}},
  author       = {{Tuli, Hardeep Singh and Garg, Vivek Kumar and Bhushan, Sakshi and Uttam, Vivek and Sharma, Uttam and Jain, Aklank and Sak, Katrin and Yadav, Vikas and Lorenzo, Jose M. and Dhama, Kuldeep and Behl, Tapan and Sethi, Gautam}},
  issn         = {{1936-5233}},
  keywords     = {{Anti-proliferation; Apoptosis; Cancer; Flavonoids; MicroRNAs; Synergism}},
  language     = {{eng}},
  publisher    = {{Neoplasia Press}},
  series       = {{Translational Oncology}},
  title        = {{Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer : A signature step hinting towards clinical perfection}},
  url          = {{http://dx.doi.org/10.1016/j.tranon.2022.101596}},
  doi          = {{10.1016/j.tranon.2022.101596}},
  volume       = {{27}},
  year         = {{2023}},
}