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EEG Frequency Correlates with α2-Receptor Density in Parkinson’s Disease

Kemp, Adam F. ; Kinnerup, Martin ; Johnsen, Birger ; Jakobsen, Steen ; Nahimi, Adjmal LU and Gjedde, Albert (2024) In Biomolecules 14(2).
Abstract

Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson’s disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cognitive impairment and the pathological slowing of EEG waves. Here, we test the relationship between the number of noradrenergic α2 adrenoceptors and changes in the spectral EEG ratio in patients with PD. Methods: We included nineteen patients with PD and thirteen healthy control (HC) subjects in the study. We used positron emission... (More)

Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson’s disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cognitive impairment and the pathological slowing of EEG waves. Here, we test the relationship between the number of noradrenergic α2 adrenoceptors and changes in the spectral EEG ratio in patients with PD. Methods: We included nineteen patients with PD and thirteen healthy control (HC) subjects in the study. We used positron emission tomography (PET) with [11C]yohimbine to quantify α2 adrenoceptor density. We used EEG power in the delta (δ, 1.5–3.9 Hz), theta (θ, 4–7.9 Hz), alpha (α, 8–12.9 Hz) and beta (β, 13–30 Hz) bands in regression analyses to test the relationships between α2 adrenoceptor density and EEG band power. Results: PD patients had higher power in the theta and delta bands compared to the HC volunteers. Patients’ theta band power was inversely correlated with α2 adrenoceptor density in the frontal cortex. In the HC subjects, age was correlated with, and occipital background rhythm frequency (BRF) was inversely correlated with, α2 adrenoceptor density in the frontal cortex, while occipital BRF was inversely correlated with α2 adrenoceptor density in the thalamus. Conclusions: The findings support the claim that the loss or dysfunction of noradrenergic neurotransmission may relate to the parallel processes of cognitive decline and EEG slowing.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dementia, EEG, locus coeruleus, noradrenaline, Parkinson’s, α adrenoceptor
in
Biomolecules
volume
14
issue
2
article number
209
publisher
MDPI AG
external identifiers
  • pmid:38397446
  • scopus:85185970725
ISSN
2218-273X
DOI
10.3390/biom14020209
language
English
LU publication?
yes
id
ec6b5653-ab46-4835-96ee-2042dca66d6d
date added to LUP
2024-03-20 11:12:26
date last changed
2024-04-17 10:39:31
@article{ec6b5653-ab46-4835-96ee-2042dca66d6d,
  abstract     = {{<p>Introduction: Increased theta and delta power and decreased alpha and beta power, measured with quantitative electroencephalography (EEG), have been demonstrated to have utility for predicting the development of dementia in patients with Parkinson’s disease (PD). Noradrenaline modulates cortical activity and optimizes cognitive processes. We claim that the loss of noradrenaline may explain cognitive impairment and the pathological slowing of EEG waves. Here, we test the relationship between the number of noradrenergic α<sub>2</sub> adrenoceptors and changes in the spectral EEG ratio in patients with PD. Methods: We included nineteen patients with PD and thirteen healthy control (HC) subjects in the study. We used positron emission tomography (PET) with [<sup>11</sup>C]yohimbine to quantify α<sub>2</sub> adrenoceptor density. We used EEG power in the delta (δ, 1.5–3.9 Hz), theta (θ, 4–7.9 Hz), alpha (α, 8–12.9 Hz) and beta (β, 13–30 Hz) bands in regression analyses to test the relationships between α<sub>2</sub> adrenoceptor density and EEG band power. Results: PD patients had higher power in the theta and delta bands compared to the HC volunteers. Patients’ theta band power was inversely correlated with α<sub>2</sub> adrenoceptor density in the frontal cortex. In the HC subjects, age was correlated with, and occipital background rhythm frequency (BRF) was inversely correlated with, α<sub>2</sub> adrenoceptor density in the frontal cortex, while occipital BRF was inversely correlated with α<sub>2</sub> adrenoceptor density in the thalamus. Conclusions: The findings support the claim that the loss or dysfunction of noradrenergic neurotransmission may relate to the parallel processes of cognitive decline and EEG slowing.</p>}},
  author       = {{Kemp, Adam F. and Kinnerup, Martin and Johnsen, Birger and Jakobsen, Steen and Nahimi, Adjmal and Gjedde, Albert}},
  issn         = {{2218-273X}},
  keywords     = {{dementia; EEG; locus coeruleus; noradrenaline; Parkinson’s; α adrenoceptor}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Biomolecules}},
  title        = {{EEG Frequency Correlates with α<sub>2</sub>-Receptor Density in Parkinson’s Disease}},
  url          = {{http://dx.doi.org/10.3390/biom14020209}},
  doi          = {{10.3390/biom14020209}},
  volume       = {{14}},
  year         = {{2024}},
}