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Diffusion tensor imaging and tractography of the white matter in normal aging : The rate-of-change differs between segments within tracts

Mårtensson, J ; Lätt, J LU ; Åhs, F ; Fredrikson, M ; Söderlund, H ; Schiöth, H B ; Kok, J ; Kremer, B ; van Westen, Danielle LU orcid and Larsson, E-M , et al. (2018) In Magnetic Resonance Imaging 45. p.113-119
Abstract

Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13... (More)

Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.

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type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Magnetic Resonance Imaging
volume
45
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:28359912
  • scopus:85042654266
ISSN
0730-725X
DOI
10.1016/j.mri.2017.03.007
language
English
LU publication?
yes
id
ec74c586-b982-4798-9680-fb7d8cdbd335
date added to LUP
2018-01-11 11:53:28
date last changed
2024-06-24 07:29:39
@article{ec74c586-b982-4798-9680-fb7d8cdbd335,
  abstract     = {{<p>Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.</p>}},
  author       = {{Mårtensson, J and Lätt, J and Åhs, F and Fredrikson, M and Söderlund, H and Schiöth, H B and Kok, J and Kremer, B and van Westen, Danielle and Larsson, E-M and Nilsson, M}},
  issn         = {{0730-725X}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  pages        = {{113--119}},
  publisher    = {{Elsevier}},
  series       = {{Magnetic Resonance Imaging}},
  title        = {{Diffusion tensor imaging and tractography of the white matter in normal aging : The rate-of-change differs between segments within tracts}},
  url          = {{http://dx.doi.org/10.1016/j.mri.2017.03.007}},
  doi          = {{10.1016/j.mri.2017.03.007}},
  volume       = {{45}},
  year         = {{2018}},
}