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The enigmatic ribosomal stalk

Liljas, Anders LU and Sanyal, Suparna LU (2018) In Quarterly Reviews of Biophysics 51.
Abstract

The large ribosomal subunit has a distinct feature, the stalk, extending outside the ribosome. In bacteria it is called the L12 stalk. The base of the stalk is protein uL10 to which two or three dimers of proteins bL12 bind. In archea and eukarya P1 and P2 proteins constitute the stalk. All these extending proteins, that have a high degree of flexibility due to a hinge between their N- and C-terminal parts, are essential for proper functionalization of some of the translation factors. The role of the stalk proteins has remained enigmatic for decades but is gradually approaching an understanding. In this review we summarise the knowhow about the structure and function of the ribosomal stalk till date starting from the early phase of... (More)

The large ribosomal subunit has a distinct feature, the stalk, extending outside the ribosome. In bacteria it is called the L12 stalk. The base of the stalk is protein uL10 to which two or three dimers of proteins bL12 bind. In archea and eukarya P1 and P2 proteins constitute the stalk. All these extending proteins, that have a high degree of flexibility due to a hinge between their N- and C-terminal parts, are essential for proper functionalization of some of the translation factors. The role of the stalk proteins has remained enigmatic for decades but is gradually approaching an understanding. In this review we summarise the knowhow about the structure and function of the ribosomal stalk till date starting from the early phase of ribosome research.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bL12, P1/P2, Ribosomal stalk, translational GTPases (trGTPases)
in
Quarterly Reviews of Biophysics
volume
51
publisher
Cambridge University Press
external identifiers
  • scopus:85063713112
ISSN
1469-8994
DOI
10.1017/S0033583518000100
language
English
LU publication?
yes
id
ec79cff0-f4e2-4a2e-a56a-29d310bcd5e6
date added to LUP
2019-04-11 14:22:20
date last changed
2019-10-13 05:00:31
@article{ec79cff0-f4e2-4a2e-a56a-29d310bcd5e6,
  abstract     = {<p>The large ribosomal subunit has a distinct feature, the stalk, extending outside the ribosome. In bacteria it is called the L12 stalk. The base of the stalk is protein uL10 to which two or three dimers of proteins bL12 bind. In archea and eukarya P1 and P2 proteins constitute the stalk. All these extending proteins, that have a high degree of flexibility due to a hinge between their N- and C-terminal parts, are essential for proper functionalization of some of the translation factors. The role of the stalk proteins has remained enigmatic for decades but is gradually approaching an understanding. In this review we summarise the knowhow about the structure and function of the ribosomal stalk till date starting from the early phase of ribosome research.</p>},
  articleno    = {e12},
  author       = {Liljas, Anders and Sanyal, Suparna},
  issn         = {1469-8994},
  keyword      = {bL12,P1/P2,Ribosomal stalk,translational GTPases (trGTPases)},
  language     = {eng},
  publisher    = {Cambridge University Press},
  series       = {Quarterly Reviews of Biophysics},
  title        = {The enigmatic ribosomal stalk},
  url          = {http://dx.doi.org/10.1017/S0033583518000100},
  volume       = {51},
  year         = {2018},
}