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Psychiatric disorders and comorbidity in women with Turner Syndrome : a retrospective national cohort study

Thunström, Sofia ; Wide, Ulla ; Landin-Wilhelmsen, Kerstin ; Berntorp, Kerstin LU ; Bryman, Inger ; Krantz, Emily ; Wahlberg, Jeanette ; Ekman, Bertil ; Isakson, Magnus and Karlsson, Anders , et al. (2024) In Translational Psychiatry 14(1).
Abstract

Turner syndrome (TS) is a genetic condition characterized by partial or complete monosomy X. A reduced life expectancy has been shown in TS, depending on an increased risk of aortic dissection, and ischemic heart disease. Studies covering the occurrence of psychiatric conditions are sparse within TS. Several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link to genetics, as well as feature correlates of TS. The aim of this study was to determine the presence, and the frequency of psychiatric diagnosis in women with TS in a Swedish cohort followed during 25 years’ time. Statistics from the entire female population in Sweden of corresponding age was used as reference. Data were... (More)

Turner syndrome (TS) is a genetic condition characterized by partial or complete monosomy X. A reduced life expectancy has been shown in TS, depending on an increased risk of aortic dissection, and ischemic heart disease. Studies covering the occurrence of psychiatric conditions are sparse within TS. Several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link to genetics, as well as feature correlates of TS. The aim of this study was to determine the presence, and the frequency of psychiatric diagnosis in women with TS in a Swedish cohort followed during 25 years’ time. Statistics from the entire female population in Sweden of corresponding age was used as reference. Data were retrieved from clinical examinations and validated from the National Board of Health and Welfare registries for women with TS (n = 487), aged 16 to 84 years, with respect to mental health disorders. The most common diagnoses in TS were mood and anxiety disorders. There was no increase in psychiatric diagnosis within the group with time, nor correlation to specific karyotype or somatic comorbidity as congenital heart disease and hypothyroidism, hormonal treatment, or childbirth. In addition, the frequency of psychiatric diagnosis in TS was lower than in the population-based data. Further investigations are needed in the view of the fact that women with Turner syndrome should not be burdened with more severe diagnoses.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Translational Psychiatry
volume
14
issue
1
article number
355
publisher
Nature Publishing Group
external identifiers
  • scopus:85203092273
  • pmid:39227579
ISSN
2158-3188
DOI
10.1038/s41398-024-02937-5
language
English
LU publication?
yes
id
ec962a7e-5d0b-44ee-9ccd-e6ba0df83235
date added to LUP
2024-11-15 10:55:05
date last changed
2025-03-07 20:17:04
@article{ec962a7e-5d0b-44ee-9ccd-e6ba0df83235,
  abstract     = {{<p>Turner syndrome (TS) is a genetic condition characterized by partial or complete monosomy X. A reduced life expectancy has been shown in TS, depending on an increased risk of aortic dissection, and ischemic heart disease. Studies covering the occurrence of psychiatric conditions are sparse within TS. Several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link to genetics, as well as feature correlates of TS. The aim of this study was to determine the presence, and the frequency of psychiatric diagnosis in women with TS in a Swedish cohort followed during 25 years’ time. Statistics from the entire female population in Sweden of corresponding age was used as reference. Data were retrieved from clinical examinations and validated from the National Board of Health and Welfare registries for women with TS (n = 487), aged 16 to 84 years, with respect to mental health disorders. The most common diagnoses in TS were mood and anxiety disorders. There was no increase in psychiatric diagnosis within the group with time, nor correlation to specific karyotype or somatic comorbidity as congenital heart disease and hypothyroidism, hormonal treatment, or childbirth. In addition, the frequency of psychiatric diagnosis in TS was lower than in the population-based data. Further investigations are needed in the view of the fact that women with Turner syndrome should not be burdened with more severe diagnoses.</p>}},
  author       = {{Thunström, Sofia and Wide, Ulla and Landin-Wilhelmsen, Kerstin and Berntorp, Kerstin and Bryman, Inger and Krantz, Emily and Wahlberg, Jeanette and Ekman, Bertil and Isakson, Magnus and Karlsson, Anders and Bergström, Ingrid and Naessén, Sabine}},
  issn         = {{2158-3188}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Translational Psychiatry}},
  title        = {{Psychiatric disorders and comorbidity in women with Turner Syndrome : a retrospective national cohort study}},
  url          = {{http://dx.doi.org/10.1038/s41398-024-02937-5}},
  doi          = {{10.1038/s41398-024-02937-5}},
  volume       = {{14}},
  year         = {{2024}},
}