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The glymphatic system : Current understanding and modeling

Bohr, Tomas ; Hjorth, Poul G. ; Holst, Sebastian C. ; Hrabětová, Sabina ; Kiviniemi, Vesa ; Lilius, Tuomas ; Lundgaard, Iben LU ; Mardal, Kent Andre ; Martens, Erik A. LU orcid and Mori, Yuki , et al. (2022) In iScience 25(9).
Abstract

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have... (More)

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Neuroanatomy, Neuroscience, Systems biology
in
iScience
volume
25
issue
9
article number
104987
publisher
Elsevier
external identifiers
  • scopus:85137084204
  • pmid:36093063
ISSN
2589-0042
DOI
10.1016/j.isci.2022.104987
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022 The Author(s)
id
ecb1d4e2-33ca-416d-a3aa-323a36960ca7
date added to LUP
2022-10-11 08:54:19
date last changed
2024-06-28 18:51:56
@article{ecb1d4e2-33ca-416d-a3aa-323a36960ca7,
  abstract     = {{<p>We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.</p>}},
  author       = {{Bohr, Tomas and Hjorth, Poul G. and Holst, Sebastian C. and Hrabětová, Sabina and Kiviniemi, Vesa and Lilius, Tuomas and Lundgaard, Iben and Mardal, Kent Andre and Martens, Erik A. and Mori, Yuki and Nägerl, U. Valentin and Nicholson, Charles and Tannenbaum, Allen and Thomas, John H. and Tithof, Jeffrey and Benveniste, Helene and Iliff, Jeffrey J. and Kelley, Douglas H. and Nedergaard, Maiken}},
  issn         = {{2589-0042}},
  keywords     = {{Neuroanatomy; Neuroscience; Systems biology}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  publisher    = {{Elsevier}},
  series       = {{iScience}},
  title        = {{The glymphatic system : Current understanding and modeling}},
  url          = {{http://dx.doi.org/10.1016/j.isci.2022.104987}},
  doi          = {{10.1016/j.isci.2022.104987}},
  volume       = {{25}},
  year         = {{2022}},
}