The glymphatic system : Current understanding and modeling
(2022) In iScience 25(9).- Abstract
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have... (More)
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.
(Less)
- author
- organization
- publishing date
- 2022-09-16
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Neuroanatomy, Neuroscience, Systems biology
- in
- iScience
- volume
- 25
- issue
- 9
- article number
- 104987
- publisher
- Elsevier
- external identifiers
-
- scopus:85137084204
- pmid:36093063
- ISSN
- 2589-0042
- DOI
- 10.1016/j.isci.2022.104987
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022 The Author(s)
- id
- ecb1d4e2-33ca-416d-a3aa-323a36960ca7
- date added to LUP
- 2022-10-11 08:54:19
- date last changed
- 2024-09-20 23:20:28
@article{ecb1d4e2-33ca-416d-a3aa-323a36960ca7, abstract = {{<p>We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.</p>}}, author = {{Bohr, Tomas and Hjorth, Poul G. and Holst, Sebastian C. and Hrabětová, Sabina and Kiviniemi, Vesa and Lilius, Tuomas and Lundgaard, Iben and Mardal, Kent Andre and Martens, Erik A. and Mori, Yuki and Nägerl, U. Valentin and Nicholson, Charles and Tannenbaum, Allen and Thomas, John H. and Tithof, Jeffrey and Benveniste, Helene and Iliff, Jeffrey J. and Kelley, Douglas H. and Nedergaard, Maiken}}, issn = {{2589-0042}}, keywords = {{Neuroanatomy; Neuroscience; Systems biology}}, language = {{eng}}, month = {{09}}, number = {{9}}, publisher = {{Elsevier}}, series = {{iScience}}, title = {{The glymphatic system : Current understanding and modeling}}, url = {{http://dx.doi.org/10.1016/j.isci.2022.104987}}, doi = {{10.1016/j.isci.2022.104987}}, volume = {{25}}, year = {{2022}}, }