Gelatine-embedded electrodes-a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes.
Lind, Gustav LU ; Eriksson Linsmeier, Cecilia LU ; Thelin, Jonas LU
and Schouenborg, Jens
LU
(2010)
In Journal of Neural Engineering
7(4).
- Abstract
- Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles... (More)
- Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles in combination with gelatine, were investigated using immunohistochemistry and fluorescence microscopy up to 12 weeks after implantation. The results indicate that pure gelatine needles were stiff enough to penetrate the brain tissue on their own, and evoked a significantly smaller chronic scar than stab wounds. Moreover, gelatine embedding appeared to reduce the acute reactions caused by the implants and we found no adverse effects of gelatine or gelatine-embedded electrodes. Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1626007
- author
- Lind, Gustav
LU
; Eriksson Linsmeier, Cecilia
LU
; Thelin, Jonas
LU
and Schouenborg, Jens
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neural Engineering
- volume
- 7
- issue
- 4
- article number
- 046005
- publisher
- IOP Publishing
- external identifiers
-
- wos:000280038600009
- pmid:20551508
- scopus:78549231632
- pmid:20551508
- ISSN
- 1741-2560
- DOI
- 10.1088/1741-2560/7/4/046005
- language
- English
- LU publication?
- yes
- id
- ecb211f3-eafe-4729-a0c8-a495db49ee4c (old id 1626007)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20551508?dopt=Abstract
- date added to LUP
- 2016-04-04 08:52:35
- date last changed
- 2024-06-09 07:50:24
@article{ecb211f3-eafe-4729-a0c8-a495db49ee4c,
abstract = {{Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles in combination with gelatine, were investigated using immunohistochemistry and fluorescence microscopy up to 12 weeks after implantation. The results indicate that pure gelatine needles were stiff enough to penetrate the brain tissue on their own, and evoked a significantly smaller chronic scar than stab wounds. Moreover, gelatine embedding appeared to reduce the acute reactions caused by the implants and we found no adverse effects of gelatine or gelatine-embedded electrodes. Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion.}},
author = {{Lind, Gustav and Eriksson Linsmeier, Cecilia and Thelin, Jonas and Schouenborg, Jens}},
issn = {{1741-2560}},
language = {{eng}},
number = {{4}},
publisher = {{IOP Publishing}},
series = {{Journal of Neural Engineering}},
title = {{Gelatine-embedded electrodes-a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes.}},
url = {{https://lup.lub.lu.se/search/files/5200127/1640646.pdf}},
doi = {{10.1088/1741-2560/7/4/046005}},
volume = {{7}},
year = {{2010}},
}