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Advances in the design and delivery of RNA vaccines for infectious diseases

Lokras, Abhijeet Girish ; Bobak, Thomas Rønnemoes ; Baghel, Saahil Sandeep ; Sebastiani, Federica LU and Foged, Camilla (2024) In Advanced Drug Delivery Reviews 213.
Abstract

RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, e.g., infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development times, which in combination with adaptability makes the RNA vaccine technology highly attractive against infectious diseases and for pandemic preparedness. Here, we review state of the art in the design and delivery of RNA vaccines for infectious diseases based on different RNA modalities, including linear mRNA, self-amplifying RNA,... (More)

RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, e.g., infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development times, which in combination with adaptability makes the RNA vaccine technology highly attractive against infectious diseases and for pandemic preparedness. Here, we review state of the art in the design and delivery of RNA vaccines for infectious diseases based on different RNA modalities, including linear mRNA, self-amplifying RNA, trans-amplifying RNA, and circular RNA. We provide an overview of the clinical pipeline of RNA vaccines for infectious diseases, and present analytical procedures, which are paramount for characterizing quality attributes and guaranteeing their quality, and we discuss future perspectives for using RNA vaccines to combat pathogens beyond SARS-CoV-2.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Delivery systems, Infectious diseases, Lipid nanoparticles, Nanomedicine, RNA, Vaccines, Vaccinology
in
Advanced Drug Delivery Reviews
volume
213
article number
115419
publisher
Elsevier
external identifiers
  • pmid:39111358
  • scopus:85201788337
ISSN
0169-409X
DOI
10.1016/j.addr.2024.115419
language
English
LU publication?
yes
id
eccac970-5470-47e9-af93-22a089e043d6
date added to LUP
2024-10-30 13:26:26
date last changed
2025-07-10 11:59:10
@article{eccac970-5470-47e9-af93-22a089e043d6,
  abstract     = {{<p>RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, e.g., infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development times, which in combination with adaptability makes the RNA vaccine technology highly attractive against infectious diseases and for pandemic preparedness. Here, we review state of the art in the design and delivery of RNA vaccines for infectious diseases based on different RNA modalities, including linear mRNA, self-amplifying RNA, trans-amplifying RNA, and circular RNA. We provide an overview of the clinical pipeline of RNA vaccines for infectious diseases, and present analytical procedures, which are paramount for characterizing quality attributes and guaranteeing their quality, and we discuss future perspectives for using RNA vaccines to combat pathogens beyond SARS-CoV-2.</p>}},
  author       = {{Lokras, Abhijeet Girish and Bobak, Thomas Rønnemoes and Baghel, Saahil Sandeep and Sebastiani, Federica and Foged, Camilla}},
  issn         = {{0169-409X}},
  keywords     = {{Delivery systems; Infectious diseases; Lipid nanoparticles; Nanomedicine; RNA; Vaccines; Vaccinology}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Advanced Drug Delivery Reviews}},
  title        = {{Advances in the design and delivery of RNA vaccines for infectious diseases}},
  url          = {{http://dx.doi.org/10.1016/j.addr.2024.115419}},
  doi          = {{10.1016/j.addr.2024.115419}},
  volume       = {{213}},
  year         = {{2024}},
}