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Diagnostic properties of metabolic perturbations in rheumatoid arthritis

Madsen, Rasmus K. ; Lundstedt, Torbjorn ; Gabrielsson, Jon ; Sennbro, Carl Johan LU ; Alenius, Gerd-Marie ; Moritz, Thomas ; Rantapaa-Dahlqvist, Solbritt and Trygg, Johan (2011) In Arthritis Research and Therapy 13(1).
Abstract
Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study... (More)
Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
13
issue
1
article number
R19
publisher
BioMed Central (BMC)
external identifiers
  • wos:000289523500030
  • scopus:79551689052
  • pmid:21303541
ISSN
1478-6362
DOI
10.1186/ar3243
language
English
LU publication?
yes
id
ecd8df50-f4d5-4147-add7-1c91ca524c38 (old id 1966036)
date added to LUP
2016-04-01 09:48:27
date last changed
2025-04-04 15:21:03
@article{ecd8df50-f4d5-4147-add7-1c91ca524c38,
  abstract     = {{Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides.}},
  author       = {{Madsen, Rasmus K. and Lundstedt, Torbjorn and Gabrielsson, Jon and Sennbro, Carl Johan and Alenius, Gerd-Marie and Moritz, Thomas and Rantapaa-Dahlqvist, Solbritt and Trygg, Johan}},
  issn         = {{1478-6362}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Arthritis Research and Therapy}},
  title        = {{Diagnostic properties of metabolic perturbations in rheumatoid arthritis}},
  url          = {{https://lup.lub.lu.se/search/files/1271449/1975832.pdf}},
  doi          = {{10.1186/ar3243}},
  volume       = {{13}},
  year         = {{2011}},
}