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A short history of chromosome rearrangements and gene fusions in cancer

Mitelman, Felix LU (2015) In Chromosomal Translocations and Genome Rearrangements in Cancer p.3-11
Abstract

The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for cytogenetically undetectable fusions, and such studies have dramatically changed the gene fusion landscape. A myriad of new gene fusions-more than 1,300-the great majority involving previously unsuspected genes, have been identified by sequencing-based analyses during the past 10 years.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Chromosome aberrations, Cytogenetics, Gene fusions, Karyotype, Oncogenes
in
Chromosomal Translocations and Genome Rearrangements in Cancer
editor
Rowley, J D; Le Beau, M M; Rabbitts, T H; ; and
pages
9 pages
publisher
Springer International Publishing
external identifiers
  • scopus:85016752768
ISBN
9783319199825
9783319199832
DOI
10.1007/978-3-319-19983-2_1
language
English
LU publication?
yes
id
ed087e42-f29f-4a0b-b461-56d4bb964331
date added to LUP
2017-05-03 15:03:59
date last changed
2017-05-03 15:03:59
@inbook{ed087e42-f29f-4a0b-b461-56d4bb964331,
  abstract     = {<p>The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for cytogenetically undetectable fusions, and such studies have dramatically changed the gene fusion landscape. A myriad of new gene fusions-more than 1,300-the great majority involving previously unsuspected genes, have been identified by sequencing-based analyses during the past 10 years.</p>},
  author       = {Mitelman, Felix},
  editor       = {Rowley, J D and Le Beau, M M and Rabbitts, T H},
  isbn         = {9783319199825},
  keyword      = {Chromosome aberrations,Cytogenetics,Gene fusions,Karyotype,Oncogenes},
  language     = {eng},
  pages        = {3--11},
  publisher    = {Springer International Publishing},
  series       = {Chromosomal Translocations and Genome Rearrangements in Cancer},
  title        = {A short history of chromosome rearrangements and gene fusions in cancer},
  url          = {http://dx.doi.org/10.1007/978-3-319-19983-2_1},
  year         = {2015},
}