Midlife Intakes of the Isoflavone Genistein and Soy and the Risk of Late-life Cognitive Impairment : The JPHC Saku Mental Health Study
(2023) In Journal of Epidemiology 33(7). p.342-349- Abstract
Background: The number of people with cognitive impairment, including dementia, in the world is steadily increasing. Although the consumption of isoflavones and soy is associated with a reduced risk of cardiovascular disease, it might also be associated with cognitive impairment. The low number of studies investigating the association between soy/isoflavone intake and cognitive function warrant additional research. Methods: The Japan Public Health Center-based prospective (JPHC) Study is a large population-based cohort. Midlife dietary intake of soy and the isoflavone genistein was assessed on two occasions: in the years 1995 and 2000. In 2014–2015, 1,299 participants from Nagano prefecture completed a mental health screening. Of these,... (More)
Background: The number of people with cognitive impairment, including dementia, in the world is steadily increasing. Although the consumption of isoflavones and soy is associated with a reduced risk of cardiovascular disease, it might also be associated with cognitive impairment. The low number of studies investigating the association between soy/isoflavone intake and cognitive function warrant additional research. Methods: The Japan Public Health Center-based prospective (JPHC) Study is a large population-based cohort. Midlife dietary intake of soy and the isoflavone genistein was assessed on two occasions: in the years 1995 and 2000. In 2014–2015, 1,299 participants from Nagano prefecture completed a mental health screening. Of these, a total of 1,036 participants were included in analyses. Logistic regression was used to determine Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between midlife energy-adjusted genistein and soy food intake and cognitive impairment. Results: There were 392 cases of cognitive impairment (346 cases of MCI and 46 cases of dementia). Compared to the lowest dietary quartile of energy-adjusted genistein intake, the highest quartile was significantly associated with cognitive impairment (OR = 1.51; 95% CI, 1.02–2.24; P for trend = 0.03) in the final multivariable analysis. Conclusion: High midlife intake of the isoflavone genistein is associated with late-life cognitive impairment.
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- author
- Svensson, Thomas LU ; Sawada, Norie ; Mimura, Masaru ; Nozaki, Shoko ; Shikimoto, Ryo and Tsugane, Shoichiro
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dementia, general population cohort, isoflavones, late-life, midlife, mild cognitive impairment, soy foods
- in
- Journal of Epidemiology
- volume
- 33
- issue
- 7
- pages
- 342 - 349
- publisher
- Elsevier
- external identifiers
-
- pmid:34924453
- scopus:85136989965
- ISSN
- 0917-5040
- DOI
- 10.2188/jea.JE20210199
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021, Japan Epidemiology Association. All rights reserved.
- id
- ed28453c-08e5-474d-a6dc-10ba93c83df8
- date added to LUP
- 2023-10-10 04:21:17
- date last changed
- 2024-04-19 02:11:32
@article{ed28453c-08e5-474d-a6dc-10ba93c83df8,
abstract = {{<p>Background: The number of people with cognitive impairment, including dementia, in the world is steadily increasing. Although the consumption of isoflavones and soy is associated with a reduced risk of cardiovascular disease, it might also be associated with cognitive impairment. The low number of studies investigating the association between soy/isoflavone intake and cognitive function warrant additional research. Methods: The Japan Public Health Center-based prospective (JPHC) Study is a large population-based cohort. Midlife dietary intake of soy and the isoflavone genistein was assessed on two occasions: in the years 1995 and 2000. In 2014–2015, 1,299 participants from Nagano prefecture completed a mental health screening. Of these, a total of 1,036 participants were included in analyses. Logistic regression was used to determine Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between midlife energy-adjusted genistein and soy food intake and cognitive impairment. Results: There were 392 cases of cognitive impairment (346 cases of MCI and 46 cases of dementia). Compared to the lowest dietary quartile of energy-adjusted genistein intake, the highest quartile was significantly associated with cognitive impairment (OR = 1.51; 95% CI, 1.02–2.24; P for trend = 0.03) in the final multivariable analysis. Conclusion: High midlife intake of the isoflavone genistein is associated with late-life cognitive impairment.</p>}},
author = {{Svensson, Thomas and Sawada, Norie and Mimura, Masaru and Nozaki, Shoko and Shikimoto, Ryo and Tsugane, Shoichiro}},
issn = {{0917-5040}},
keywords = {{dementia; general population cohort; isoflavones; late-life; midlife; mild cognitive impairment; soy foods}},
language = {{eng}},
number = {{7}},
pages = {{342--349}},
publisher = {{Elsevier}},
series = {{Journal of Epidemiology}},
title = {{Midlife Intakes of the Isoflavone Genistein and Soy and the Risk of Late-life Cognitive Impairment : The JPHC Saku Mental Health Study}},
url = {{http://dx.doi.org/10.2188/jea.JE20210199}},
doi = {{10.2188/jea.JE20210199}},
volume = {{33}},
year = {{2023}},
}