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Lithium evokes a more pronounced natriuresis when administered orally than when given intravenously to salt-depleted rats

Mu, Jianying; Johansson, Martin LU ; Hansson, Gunnar C. and Lundgren, Ove (1999) In Pflügers Archiv 438(2). p.159-164
Abstract

The effects on renal sodium excretion of giving lithium chloride (LiCl; 0.75 mmol per kg body mass) by gavage or intravenously were investigated. The experiments were carried out on Wistar-Kyoto (WKY) or spontaneously hypertensive (SHR) rats in metabolic cages. The rats had been on a low-salt diet for 4 days. Urine excretion of water, sodium and potassium was followed before and for 24 h after giving LiCl. An oral dose of LiCl evoked a more pronounced renal sodium excretion in either strain of rat as compared to that following intravenous administration, in agreement with previous observations of the effects of giving sodium chloride. Choline chloride (1.5 mmol per kg body mass) given by gavage to WKY rats or SHR evoked no change in the... (More)

The effects on renal sodium excretion of giving lithium chloride (LiCl; 0.75 mmol per kg body mass) by gavage or intravenously were investigated. The experiments were carried out on Wistar-Kyoto (WKY) or spontaneously hypertensive (SHR) rats in metabolic cages. The rats had been on a low-salt diet for 4 days. Urine excretion of water, sodium and potassium was followed before and for 24 h after giving LiCl. An oral dose of LiCl evoked a more pronounced renal sodium excretion in either strain of rat as compared to that following intravenous administration, in agreement with previous observations of the effects of giving sodium chloride. Choline chloride (1.5 mmol per kg body mass) given by gavage to WKY rats or SHR evoked no change in the renal excretion of sodium. Based on the results of the present study and on observations reported in the literature, we propose that the intestinal tract contains a sodium 'sensor', which upon activation releases a natriuretic factor to cause renal sodium excretion. The present results indicate that the proposed 'sensor' is sensitive to lithium but not chloride ions.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Intestine, Kidney, Lithium, Natriuresis, Sodium
in
Pflügers Archiv
volume
438
issue
2
pages
159 - 164
publisher
Springer
external identifiers
  • scopus:0032967282
ISSN
0031-6768
DOI
10.1007/s004240050894
language
English
LU publication?
no
id
ed68d844-8cbd-4ee8-abb2-d43d4773b231
date added to LUP
2017-04-10 16:55:43
date last changed
2017-04-10 16:55:43
@article{ed68d844-8cbd-4ee8-abb2-d43d4773b231,
  abstract     = {<p>The effects on renal sodium excretion of giving lithium chloride (LiCl; 0.75 mmol per kg body mass) by gavage or intravenously were investigated. The experiments were carried out on Wistar-Kyoto (WKY) or spontaneously hypertensive (SHR) rats in metabolic cages. The rats had been on a low-salt diet for 4 days. Urine excretion of water, sodium and potassium was followed before and for 24 h after giving LiCl. An oral dose of LiCl evoked a more pronounced renal sodium excretion in either strain of rat as compared to that following intravenous administration, in agreement with previous observations of the effects of giving sodium chloride. Choline chloride (1.5 mmol per kg body mass) given by gavage to WKY rats or SHR evoked no change in the renal excretion of sodium. Based on the results of the present study and on observations reported in the literature, we propose that the intestinal tract contains a sodium 'sensor', which upon activation releases a natriuretic factor to cause renal sodium excretion. The present results indicate that the proposed 'sensor' is sensitive to lithium but not chloride ions.</p>},
  author       = {Mu, Jianying and Johansson, Martin and Hansson, Gunnar C. and Lundgren, Ove},
  issn         = {0031-6768},
  keyword      = {Intestine,Kidney,Lithium,Natriuresis,Sodium},
  language     = {eng},
  number       = {2},
  pages        = {159--164},
  publisher    = {Springer},
  series       = {Pflügers Archiv},
  title        = {Lithium evokes a more pronounced natriuresis when administered orally than when given intravenously to salt-depleted rats},
  url          = {http://dx.doi.org/10.1007/s004240050894},
  volume       = {438},
  year         = {1999},
}