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Chromosome aberrations in psoriatic patients treated with arsenic

Nordenson, I ; Salmonsson, S ; Brun, E LU and Beckman, G (1979) In Human Genetics 48(1). p.1-6
Abstract

A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Aged, Arsenic/adverse effects, Chromatids/drug effects, Chromosome Aberrations, Crossing Over, Genetic/drug effects, Female, Humans, Lymphocytes/ultrastructure, Male, Middle Aged, Psoriasis/drug therapy, Time Factors
in
Human Genetics
volume
48
issue
1
pages
6 pages
publisher
Springer
external identifiers
  • scopus:0018286961
  • pmid:457124
ISSN
0340-6717
language
English
LU publication?
no
id
ed8427c8-12b3-4abb-8d81-b701f97b1f59
date added to LUP
2019-07-01 14:09:01
date last changed
2024-01-01 15:06:19
@article{ed8427c8-12b3-4abb-8d81-b701f97b1f59,
  abstract     = {{<p>A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.</p>}},
  author       = {{Nordenson, I and Salmonsson, S and Brun, E and Beckman, G}},
  issn         = {{0340-6717}},
  keywords     = {{Adult; Aged; Arsenic/adverse effects; Chromatids/drug effects; Chromosome Aberrations; Crossing Over, Genetic/drug effects; Female; Humans; Lymphocytes/ultrastructure; Male; Middle Aged; Psoriasis/drug therapy; Time Factors}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  pages        = {{1--6}},
  publisher    = {{Springer}},
  series       = {{Human Genetics}},
  title        = {{Chromosome aberrations in psoriatic patients treated with arsenic}},
  volume       = {{48}},
  year         = {{1979}},
}