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The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications.

Nilsson, Malin K LU ; Zheng, Ming H and Tägil, Magnus LU (2013) In Expert Review of Medical Devices 10(5). p.675-684
Abstract
Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics... (More)
Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Expert Review of Medical Devices
volume
10
issue
5
pages
675 - 684
publisher
Expert Reviews
external identifiers
  • wos:000324647000017
  • pmid:24053255
  • scopus:84886923527
  • pmid:24053255
ISSN
1745-2422
DOI
10.1586/17434440.2013.827529
language
English
LU publication?
yes
id
ed8dfe12-2c0a-4133-bc9d-36beec05e02c (old id 4065581)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24053255?dopt=Abstract
date added to LUP
2016-04-01 10:57:49
date last changed
2019-11-05 01:35:10
@article{ed8dfe12-2c0a-4133-bc9d-36beec05e02c,
  abstract     = {Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future.},
  author       = {Nilsson, Malin K and Zheng, Ming H and Tägil, Magnus},
  issn         = {1745-2422},
  language     = {eng},
  number       = {5},
  pages        = {675--684},
  publisher    = {Expert Reviews},
  series       = {Expert Review of Medical Devices},
  title        = {The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications.},
  url          = {http://dx.doi.org/10.1586/17434440.2013.827529},
  doi          = {10.1586/17434440.2013.827529},
  volume       = {10},
  year         = {2013},
}