Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis : The DIET-HD Study
(2022) In Nutrients 14(19).- Abstract
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in... (More)
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.
(Less)
- author
- Su, Guobin ; Saglimbene, Valeria ; Wong, Germaine ; Bernier-Jean, Amélie ; Carrero, Juan Jesus ; Natale, Patrizia ; Ruospo, Marinella ; Hegbrant, Jorgen LU ; Craig, Jonathan C. and Strippoli, Giovanni F.M.
- organization
- publishing date
- 2022-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cohort, DIET-HD, haemodialysis, mortality, phosphorus, plant-base
- in
- Nutrients
- volume
- 14
- issue
- 19
- article number
- 4064
- publisher
- MDPI AG
- external identifiers
-
- scopus:85139854977
- pmid:36235716
- ISSN
- 2072-6643
- DOI
- 10.3390/nu14194064
- language
- English
- LU publication?
- yes
- id
- edd41763-fd01-45a4-b1ad-4a9b5edbb1d3
- date added to LUP
- 2022-12-14 15:49:14
- date last changed
- 2024-10-29 07:10:28
@article{edd41763-fd01-45a4-b1ad-4a9b5edbb1d3,
abstract = {{<p>Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.</p>}},
author = {{Su, Guobin and Saglimbene, Valeria and Wong, Germaine and Bernier-Jean, Amélie and Carrero, Juan Jesus and Natale, Patrizia and Ruospo, Marinella and Hegbrant, Jorgen and Craig, Jonathan C. and Strippoli, Giovanni F.M.}},
issn = {{2072-6643}},
keywords = {{cohort; DIET-HD; haemodialysis; mortality; phosphorus; plant-base}},
language = {{eng}},
number = {{19}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis : The DIET-HD Study}},
url = {{http://dx.doi.org/10.3390/nu14194064}},
doi = {{10.3390/nu14194064}},
volume = {{14}},
year = {{2022}},
}