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Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena; Muller, David C; Lagiou, P; Ahrens, Wolfgang; Holcátová, Ivana; Merletti, Franco; Kjærheim, Kristina; Polesel, Jerry; Simonato, Lorenzo and Canova, Cristina, et al. (2016) In International Journal of Epidemiology 45(3). p.61-752
Abstract

BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.

METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.

RESULTS: Both smoking [odds ratio... (More)

BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.

METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.

RESULTS: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.

CONCLUSIONS: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

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Journal Article
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International Journal of Epidemiology
volume
45
issue
3
pages
10 pages
publisher
Oxford University Press
external identifiers
  • wos:000384653200029
ISSN
1464-3685
DOI
10.1093/ije/dyw069
language
English
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yes
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ee36fb8b-9d06-4474-a0cc-77df864f16ee
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2017-02-13 15:50:49
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2017-10-16 12:48:25
@article{ee36fb8b-9d06-4474-a0cc-77df864f16ee,
  abstract     = {<p>BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.</p><p>METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.</p><p>RESULTS: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.</p><p>CONCLUSIONS: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.</p>},
  author       = {Anantharaman, Devasena and Muller, David C and Lagiou, P and Ahrens, Wolfgang and Holcátová, Ivana and Merletti, Franco and Kjærheim, Kristina and Polesel, Jerry and Simonato, Lorenzo and Canova, Cristina and Castellsague, Xavier and Macfarlane, Tatiana V and Znaor, Ariana and Thomson, Peter and Robinson, Max and Conway, David I and Healy, Claire M and Tjønneland, Anne and Westin, Ulla and Ekström, Johanna and Chang-Claude, Jenny and Kaaks, Rudolf and Overvad, Kim and Drogan, Dagmar and Hallmans, Göran and Laurell, Göran and Bueno-de-Mesquita, H B and Peeters, Petra H. and Agudo, Antonio and Larrañaga, Nerea and Travis, Ruth C and Palli, Domenico and Barricarte, Aurelio and Trichopoulou, Antonia and George, Saitakis and Trichopoulos, Dimitrios and Quirós, J Ramón and Grioni, Sara and Sacerdote, Carlotta and Navarro, Carmen and Sánchez, María-José and Tumino, Rosario and Severi, Gianluca and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Panico, Salvatore and Weiderpass, Elisabete and Lund, Eiliv and Gram, Inger T and Riboli, Elio and Pawlita, Michael and Waterboer, Tim and Kreimer, Aimée R and Johansson, Mattias and Brennan, Paul},
  issn         = {1464-3685},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {3},
  pages        = {61--752},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Combined effects of smoking and HPV16 in oropharyngeal cancer},
  url          = {http://dx.doi.org/10.1093/ije/dyw069},
  volume       = {45},
  year         = {2016},
}