Feber og hudblødninger hos børn--er det meningokoksygdom?
(2002) In Ugeskrift for Laeger 164(20). p.2617-2623- Abstract
INTRODUCTION: Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.
MATERIALS AND METHODS: This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.
RESULTS: We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum... (More)
INTRODUCTION: Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.
MATERIALS AND METHODS: This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.
RESULTS: We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum diameter of > 2 mm; (4) poor general condition; and (5) nuchal rigidity.
DISCUSSION: If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false-positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.
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- author
- Nielsen, Hans Erik ; Andersen, Erik Arthur ; Andersen, Jesper ; Böttiger, Blenda LU ; Christiansen, Karsten Maidahl ; Daugbjerg, Peder Stjernholm ; Larsen, Severin Olesen ; Lind, Inga ; Nir, Marta and Olofsson, Kern
- alternative title
- Fever and skin hemorrhages in children--is it meningococcal disease?
- publishing date
- 2002-05-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Child, Child, Preschool, Diagnosis, Differential, Fever/diagnosis, Hemorrhage/diagnosis, Humans, Infant, Meningitis, Bacterial/diagnosis, Meningitis, Viral/diagnosis, Meningococcal Infections/diagnosis, Microbiological Techniques, Prospective Studies, Skin/pathology, Skin Diseases, Bacterial/diagnosis, Skin Diseases, Viral/diagnosis
- in
- Ugeskrift for Laeger
- volume
- 164
- issue
- 20
- pages
- 7 pages
- publisher
- Den Almindelige Danske Lægeforening
- external identifiers
-
- pmid:12043405
- scopus:4243381878
- ISSN
- 0041-5782
- language
- Danish
- LU publication?
- no
- id
- ee39c04c-d015-438f-8f81-58d064c5da61
- alternative location
- http://ugeskriftet.dk/videnskab/feber-og-hudbloedninger-hos-boern-er-det-meningokoksygdom
- date added to LUP
- 2019-05-02 14:31:35
- date last changed
- 2024-01-01 02:36:10
@article{ee39c04c-d015-438f-8f81-58d064c5da61,
abstract = {{<p>INTRODUCTION: Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.</p><p>MATERIALS AND METHODS: This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.</p><p>RESULTS: We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum diameter of > 2 mm; (4) poor general condition; and (5) nuchal rigidity.</p><p>DISCUSSION: If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false-positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.</p>}},
author = {{Nielsen, Hans Erik and Andersen, Erik Arthur and Andersen, Jesper and Böttiger, Blenda and Christiansen, Karsten Maidahl and Daugbjerg, Peder Stjernholm and Larsen, Severin Olesen and Lind, Inga and Nir, Marta and Olofsson, Kern}},
issn = {{0041-5782}},
keywords = {{Child; Child, Preschool; Diagnosis, Differential; Fever/diagnosis; Hemorrhage/diagnosis; Humans; Infant; Meningitis, Bacterial/diagnosis; Meningitis, Viral/diagnosis; Meningococcal Infections/diagnosis; Microbiological Techniques; Prospective Studies; Skin/pathology; Skin Diseases, Bacterial/diagnosis; Skin Diseases, Viral/diagnosis}},
language = {{dan}},
month = {{05}},
number = {{20}},
pages = {{2617--2623}},
publisher = {{Den Almindelige Danske Lægeforening}},
series = {{Ugeskrift for Laeger}},
title = {{Feber og hudblødninger hos børn--er det meningokoksygdom?}},
url = {{http://ugeskriftet.dk/videnskab/feber-og-hudbloedninger-hos-boern-er-det-meningokoksygdom}},
volume = {{164}},
year = {{2002}},
}