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Valid Exposure Protocols Needed in Magnetic Resonance Imaging Genotoxic Research

Wilén, Jonna ; Olsrud, Johan LU ; Frankel, Jennifer and Hansson Mild, Kjell (2020) In Bioelectromagnetics 41(3). p.247-257
Abstract

Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not... (More)

Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not the case with many of the recent studies on MRI and genotoxicity. Here we discuss what is lacking in previous studies, and how we think the next generation of in vitro and in vivo studies on MRI and genotoxicity should be performed. Bioelectromagnetics.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DNA, genotoxicity, isocenter, magnetic field, pulse sequence
in
Bioelectromagnetics
volume
41
issue
3
pages
11 pages
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:32157722
  • scopus:85081679643
ISSN
0197-8462
DOI
10.1002/bem.22257
language
English
LU publication?
yes
id
ee3f073d-e4b0-49b2-8423-535b8640cdd0
date added to LUP
2020-03-30 17:00:27
date last changed
2020-04-02 02:49:49
@article{ee3f073d-e4b0-49b2-8423-535b8640cdd0,
  abstract     = {<p>Several in vitro and in vivo studies have investigated if a magnetic resonance imaging (MRI) examination can cause DNA damage in human blood cells. However, the electromagnetic field (EMF) exposure that the cells received in the MR scanner was not sufficiently described. The first studies looking into this could be regarded as hypothesis-generating studies. However, for further exploration into the role of MRI exposure on DNA integrity, the exposure itself cannot be ignored. The lack of sufficient method descriptions makes the early experiments difficult, if not impossible, to repeat. The golden rule in all experimental work is that a study should be repeatable by someone with the right knowledge and equipment, and this is simply not the case with many of the recent studies on MRI and genotoxicity. Here we discuss what is lacking in previous studies, and how we think the next generation of in vitro and in vivo studies on MRI and genotoxicity should be performed. Bioelectromagnetics.</p>},
  author       = {Wilén, Jonna and Olsrud, Johan and Frankel, Jennifer and Hansson Mild, Kjell},
  issn         = {0197-8462},
  language     = {eng},
  number       = {3},
  pages        = {247--257},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Bioelectromagnetics},
  title        = {Valid Exposure Protocols Needed in Magnetic Resonance Imaging Genotoxic Research},
  url          = {http://dx.doi.org/10.1002/bem.22257},
  doi          = {10.1002/bem.22257},
  volume       = {41},
  year         = {2020},
}