Use of PET/CT instead of CT-only when planning for radiation therapy does not notably increase life years lost in children being treated for cancer
Kornerup, Josefine S. ; Brodin, Patrik ; Birk Christensen, Charlotte ; Björk-Eriksson, Thomas ; Kiil-Berthelsen, Anne ; Borgwardt, Lise and Munck af Rosenschöld, Per LU
(2015)
In Pediatric Radiology
45(4).
p.570-581
- Abstract
Background: PET/CT may be more helpful than CT alone for radiation therapy planning, but the added risk due to higher doses of ionizing radiation is unknown. Objective: To estimate the risk of cancer induction and mortality attributable to the [F-18]2-fluoro-2-deoxyglucose (FDG) PET and CT scans used for radiation therapy planning in children with cancer, and compare to the risks attributable to the cancer treatment. Materials and methods: Organ doses and effective doses were estimated for 40 children (2–18 years old) who had been scanned using PET/CT as part of radiation therapy planning. The risk of inducing secondary cancer was estimated using the models in BEIR VII. The prognosis of an induced cancer was taken into account and the... (More)
Background: PET/CT may be more helpful than CT alone for radiation therapy planning, but the added risk due to higher doses of ionizing radiation is unknown. Objective: To estimate the risk of cancer induction and mortality attributable to the [F-18]2-fluoro-2-deoxyglucose (FDG) PET and CT scans used for radiation therapy planning in children with cancer, and compare to the risks attributable to the cancer treatment. Materials and methods: Organ doses and effective doses were estimated for 40 children (2–18 years old) who had been scanned using PET/CT as part of radiation therapy planning. The risk of inducing secondary cancer was estimated using the models in BEIR VII. The prognosis of an induced cancer was taken into account and the reduction in life expectancy, in terms of life years lost, was estimated for the diagnostics and compared to the life years lost attributable to the therapy. Multivariate linear regression was performed to find predictors for a high contribution to life years lost from the radiation therapy planning diagnostics. Results: The mean contribution from PET to the effective dose from one PET/CT scan was 24% (range: 7–64%). The average proportion of life years lost attributable to the nuclear medicine dose component from one PET/CT scan was 15% (range: 3–41%). The ratio of life years lost from the radiation therapy planning PET/CT scans and that of the cancer treatment was on average 0.02 (range: 0.01–0.09). Female gender was associated with increased life years lost from the scans (P < 0.001). Conclusion: Using FDG-PET/CT instead of CT only when defining the target volumes for radiation therapy of children with cancer does not notably increase the number of life years lost attributable to diagnostic examinations.
(Less)
- author
- Kornerup, Josefine S.
; Brodin, Patrik
; Birk Christensen, Charlotte
; Björk-Eriksson, Thomas
; Kiil-Berthelsen, Anne
; Borgwardt, Lise
and Munck af Rosenschöld, Per
LU
- publishing date
- 2015-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Long-term complications, Pediatric, Positron emission tomography/computed tomography (PET/CT), Radiation therapy planning, Risk estimation
- in
- Pediatric Radiology
- volume
- 45
- issue
- 4
- pages
- 570 - 581
- publisher
- Springer
- external identifiers
-
- pmid:25378209
- scopus:84939941089
- ISSN
- 0301-0449
- DOI
- 10.1007/s00247-014-3197-4
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2014, Springer-Verlag Berlin Heidelberg.
- id
- ee51c205-9d95-4348-a10d-b206d82f52a5
- date added to LUP
- 2023-07-19 17:06:37
- date last changed
- 2024-01-05 03:32:50
@article{ee51c205-9d95-4348-a10d-b206d82f52a5,
abstract = {{<p>Background: PET/CT may be more helpful than CT alone for radiation therapy planning, but the added risk due to higher doses of ionizing radiation is unknown. Objective: To estimate the risk of cancer induction and mortality attributable to the [F-18]2-fluoro-2-deoxyglucose (FDG) PET and CT scans used for radiation therapy planning in children with cancer, and compare to the risks attributable to the cancer treatment. Materials and methods: Organ doses and effective doses were estimated for 40 children (2–18 years old) who had been scanned using PET/CT as part of radiation therapy planning. The risk of inducing secondary cancer was estimated using the models in BEIR VII. The prognosis of an induced cancer was taken into account and the reduction in life expectancy, in terms of life years lost, was estimated for the diagnostics and compared to the life years lost attributable to the therapy. Multivariate linear regression was performed to find predictors for a high contribution to life years lost from the radiation therapy planning diagnostics. Results: The mean contribution from PET to the effective dose from one PET/CT scan was 24% (range: 7–64%). The average proportion of life years lost attributable to the nuclear medicine dose component from one PET/CT scan was 15% (range: 3–41%). The ratio of life years lost from the radiation therapy planning PET/CT scans and that of the cancer treatment was on average 0.02 (range: 0.01–0.09). Female gender was associated with increased life years lost from the scans (P < 0.001). Conclusion: Using FDG-PET/CT instead of CT only when defining the target volumes for radiation therapy of children with cancer does not notably increase the number of life years lost attributable to diagnostic examinations.</p>}},
author = {{Kornerup, Josefine S. and Brodin, Patrik and Birk Christensen, Charlotte and Björk-Eriksson, Thomas and Kiil-Berthelsen, Anne and Borgwardt, Lise and Munck af Rosenschöld, Per}},
issn = {{0301-0449}},
keywords = {{Long-term complications; Pediatric; Positron emission tomography/computed tomography (PET/CT); Radiation therapy planning; Risk estimation}},
language = {{eng}},
month = {{04}},
number = {{4}},
pages = {{570--581}},
publisher = {{Springer}},
series = {{Pediatric Radiology}},
title = {{Use of PET/CT instead of CT-only when planning for radiation therapy does not notably increase life years lost in children being treated for cancer}},
url = {{http://dx.doi.org/10.1007/s00247-014-3197-4}},
doi = {{10.1007/s00247-014-3197-4}},
volume = {{45}},
year = {{2015}},
}