WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex
(2011) In Genes & Development 25(19). p.2025-2030- Abstract
- WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where it activates CLV3 transcription by binding to its promoter elements. Using a computational model, we show that maintenance of the WUS gradient is essential to regulate stem cell number. Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme... (More)
- WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where it activates CLV3 transcription by binding to its promoter elements. Using a computational model, we show that maintenance of the WUS gradient is essential to regulate stem cell number. Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme that is unique to plant stem cell niches. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2212790
- author
- Yadav, Ram Kishor ; Perales, Mariano ; Gruel, Jeremy ; Girke, Thomas ; Jönsson, Henrik LU and Reddy, G. Venugopala
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CLAVATA3, shoot apical meristem, CLAVATA1, central zone, niche
- in
- Genes & Development
- volume
- 25
- issue
- 19
- pages
- 2025 - 2030
- publisher
- Cold Spring Harbor Laboratory Press (CSHL)
- external identifiers
-
- wos:000295775600003
- scopus:80053629973
- pmid:21979915
- ISSN
- 1549-5477
- DOI
- 10.1101/gad.17258511
- language
- English
- LU publication?
- yes
- id
- ee56ecfa-5527-40b6-86b1-bfb3434d5998 (old id 2212790)
- date added to LUP
- 2016-04-01 14:27:53
- date last changed
- 2024-04-10 20:38:28
@article{ee56ecfa-5527-40b6-86b1-bfb3434d5998, abstract = {{WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where it activates CLV3 transcription by binding to its promoter elements. Using a computational model, we show that maintenance of the WUS gradient is essential to regulate stem cell number. Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme that is unique to plant stem cell niches.}}, author = {{Yadav, Ram Kishor and Perales, Mariano and Gruel, Jeremy and Girke, Thomas and Jönsson, Henrik and Reddy, G. Venugopala}}, issn = {{1549-5477}}, keywords = {{CLAVATA3; shoot apical meristem; CLAVATA1; central zone; niche}}, language = {{eng}}, number = {{19}}, pages = {{2025--2030}}, publisher = {{Cold Spring Harbor Laboratory Press (CSHL)}}, series = {{Genes & Development}}, title = {{WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex}}, url = {{http://dx.doi.org/10.1101/gad.17258511}}, doi = {{10.1101/gad.17258511}}, volume = {{25}}, year = {{2011}}, }