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Activation and cross-reactivity pattern of a new allergen in adhesive plaster

Bergendorff, Ola LU and Hansson, Christer LU (2000) In Contact Dermatitis 42(1). p.11-17
Abstract
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described.... (More)
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
42
issue
1
pages
11 - 17
publisher
Wiley-Blackwell
external identifiers
  • pmid:10644019
  • scopus:0033984118
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2000.042001011.x
language
English
LU publication?
yes
id
ee8dfa38-336f-4cbe-9716-17dad02fcac0 (old id 1117714)
date added to LUP
2016-04-01 12:02:46
date last changed
2022-08-13 18:23:40
@article{ee8dfa38-336f-4cbe-9716-17dad02fcac0,
  abstract     = {{N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.}},
  author       = {{Bergendorff, Ola and Hansson, Christer}},
  issn         = {{0105-1873}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11--17}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Activation and cross-reactivity pattern of a new allergen in adhesive plaster}},
  url          = {{http://dx.doi.org/10.1034/j.1600-0536.2000.042001011.x}},
  doi          = {{10.1034/j.1600-0536.2000.042001011.x}},
  volume       = {{42}},
  year         = {{2000}},
}