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Association between Serum Testosterone and PSA Levels in Middle-Aged Healthy Men from the General Population

Elzanaty, Saad LU ; Rezanezhad, Babak and Dohle, Gert (2017) In Current Urology 10(1). p.40-44
Abstract

Introduction: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. Materials and Methods: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone > 12 nmol/l). Results: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar... (More)

Introduction: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. Materials and Methods: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone > 12 nmol/l). Results: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar when compared between hypogonadal and eugonadal men (1.4 μg/l vs. 1.4 μg/l, p = 0.90).When using a multivariate analysis model adjusted for the age of the subjects, BMI, waist-to-hip ratio, smoking, and alcohol consumption, a positive significant association between testosterone and PSA levels was found (β = 0.03, 95 % CI = 0.003-0.062, p = 0.03). Conclusion: Only after adjusted multivariate analysis, our results indicated that testosterone was associated with PSA levels in middle-aged healthy men.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Eugonadal, Hypogonadal, Prostate cancer, PSA, Testosterone
in
Current Urology
volume
10
issue
1
pages
5 pages
publisher
Karger
external identifiers
  • pmid:28559776
  • scopus:85022222953
ISSN
1661-7649
DOI
10.1159/000447149
language
English
LU publication?
yes
id
ee9ac85f-a7d8-4c87-80aa-464753caa87a
date added to LUP
2017-07-25 13:41:01
date last changed
2024-04-14 14:49:28
@article{ee9ac85f-a7d8-4c87-80aa-464753caa87a,
  abstract     = {{<p>Introduction: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. Materials and Methods: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone &gt; 12 nmol/l). Results: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar when compared between hypogonadal and eugonadal men (1.4 μg/l vs. 1.4 μg/l, p = 0.90).When using a multivariate analysis model adjusted for the age of the subjects, BMI, waist-to-hip ratio, smoking, and alcohol consumption, a positive significant association between testosterone and PSA levels was found (β = 0.03, 95 % CI = 0.003-0.062, p = 0.03). Conclusion: Only after adjusted multivariate analysis, our results indicated that testosterone was associated with PSA levels in middle-aged healthy men.</p>}},
  author       = {{Elzanaty, Saad and Rezanezhad, Babak and Dohle, Gert}},
  issn         = {{1661-7649}},
  keywords     = {{Eugonadal; Hypogonadal; Prostate cancer; PSA; Testosterone}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  pages        = {{40--44}},
  publisher    = {{Karger}},
  series       = {{Current Urology}},
  title        = {{Association between Serum Testosterone and PSA Levels in Middle-Aged Healthy Men from the General Population}},
  url          = {{http://dx.doi.org/10.1159/000447149}},
  doi          = {{10.1159/000447149}},
  volume       = {{10}},
  year         = {{2017}},
}