Medical article with coated surfaces exhibiting low friction and low protein adsorption
Rasmussen, Thomas-Buch ; Jannasch, Patric LU
; Bonne-Jørgensen, Erling
; Johannesen, Ib
and Ndoni, Sokol
(1999)
AU3248099A;WO9944755A1
- Abstract
- The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of... (More)
- The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/eeba3389-a8f6-4516-8e20-9a62791dda82
- inventor
- Rasmussen, Thomas-Buch
; Jannasch, Patric
LU
; Bonne-Jørgensen, Erling
; Johannesen, Ib
and Ndoni, Sokol
- organization
- publishing date
- 1999-09-10
- type
- Patent
- publication status
- published
- subject
- patent number
- AU3248099A;WO9944755A1
- language
- English
- LU publication?
- yes
- id
- eeba3389-a8f6-4516-8e20-9a62791dda82
- alternative location
- https://worldwide.espacenet.com/patent/search/family/026063740/publication/WO9944755A1?q=Jannasch
- date added to LUP
- 2021-10-30 12:57:59
- date last changed
- 2021-11-25 12:41:42
@misc{eeba3389-a8f6-4516-8e20-9a62791dda82,
abstract = {{The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.}},
author = {{Rasmussen, Thomas-Buch and Jannasch, Patric and Bonne-Jørgensen, Erling and Johannesen, Ib and Ndoni, Sokol}},
language = {{eng}},
month = {{09}},
note = {{Patent, Patent Number: AU3248099A;WO9944755A1}},
title = {{Medical article with coated surfaces exhibiting low friction and low protein adsorption}},
url = {{https://worldwide.espacenet.com/patent/search/family/026063740/publication/WO9944755A1?q=Jannasch}},
year = {{1999}},
}