Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase
Piacham, Theeraphon LU ; Isarankura-Na-Ayuldhya, C ; Nantasenamat, C ; Yainoy, S ; Ye, Lei LU
; Bülow, Leif
LU
and Prachayasittikul, V
(2006)
In Biochemical and Biophysical Research Communications
341(4).
p.925-930
- Abstract
- Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of... (More)
- Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/416903
- author
- Piacham, Theeraphon
LU
; Isarankura-Na-Ayuldhya, C
; Nantasenamat, C
; Yainoy, S
; Ye, Lei
LU
; Bülow, Leif
LU
and Prachayasittikul, V
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- molecular, modeling, SOD mimic, SOD, superoxide dismutase, antibiotic, bacitracin
- in
- Biochemical and Biophysical Research Communications
- volume
- 341
- issue
- 4
- pages
- 925 - 930
- publisher
- Elsevier
- external identifiers
-
- wos:000235699900005
- pmid:16455051
- scopus:32344435147
- pmid:16455051
- ISSN
- 1090-2104
- DOI
- 10.1016/j.bbrc.2006.01.045
- language
- English
- LU publication?
- yes
- id
- ef71350b-48bd-4d5a-94f0-9843dfceccff (old id 416903)
- date added to LUP
- 2016-04-01 16:45:28
- date last changed
- 2022-02-27 23:22:37
@article{ef71350b-48bd-4d5a-94f0-9843dfceccff,
abstract = {{Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.}},
author = {{Piacham, Theeraphon and Isarankura-Na-Ayuldhya, C and Nantasenamat, C and Yainoy, S and Ye, Lei and Bülow, Leif and Prachayasittikul, V}},
issn = {{1090-2104}},
keywords = {{molecular; modeling; SOD mimic; SOD; superoxide dismutase; antibiotic; bacitracin}},
language = {{eng}},
number = {{4}},
pages = {{925--930}},
publisher = {{Elsevier}},
series = {{Biochemical and Biophysical Research Communications}},
title = {{Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase}},
url = {{http://dx.doi.org/10.1016/j.bbrc.2006.01.045}},
doi = {{10.1016/j.bbrc.2006.01.045}},
volume = {{341}},
year = {{2006}},
}