Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration
Wisse, L E M LU
; Das, S R
; Davatzikos, C
; Dickerson, B C
; Xie, S X
; Yushkevich, P A
and Wolk, D A
(2018)
In NeuroImage: Clinical
18.
p.407-412
- Abstract
INTRODUCTION: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneration defined by cross-sectional 'hippocampal volume' only (SNAP/L-) versus both cross-sectional and longitudinal 'hippocampal atrophy rate' (SNAP/L+) and investigate how these definitions impact prevalence and the clinical and biomarker profile of SNAP in Mild Cognitive Impairment (MCI).
METHODS: 276 MCI patients from ADNI-GO/2 were... (More)
INTRODUCTION: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneration defined by cross-sectional 'hippocampal volume' only (SNAP/L-) versus both cross-sectional and longitudinal 'hippocampal atrophy rate' (SNAP/L+) and investigate how these definitions impact prevalence and the clinical and biomarker profile of SNAP in Mild Cognitive Impairment (MCI).
METHODS: 276 MCI patients from ADNI-GO/2 were designated amyloid "positive" (A+) or "negative" (A-) based on their florbetapir scan and neurodegeneration 'positive' or 'negative' based on cross-sectional hippocampal volume and longitudinal hippocampal atrophy rate.
RESULTS: 74.1% of all SNAP participants defined by the cross-sectional definition of neurodegeneration also met the longitudinal definition of neurodegeneration, whereas 25.9% did not. SNAP/L+ displayed larger white matter hyperintensity volume, a higher conversion rate to dementia over 5 years and a steeper decline on cognitive tasks compared to SNAP/L- and the A- CN group. SNAP/L- had more abnormal values on neuroimaging markers and worse performance on cognitive tasks than the A- CN group, but did not show a difference in dementia conversion rate or longitudinal cognition.
DISCUSSION: Using a longitudinal definition of neurodegeneration in addition to a cross-sectional one identifies SNAP participants with significant cognitive decline and a worse clinical prognosis for which cerebrovascular disease may be an important driver.
(Less)
- author
- Wisse, L E M
LU
; Das, S R
; Davatzikos, C
; Dickerson, B C
; Xie, S X
; Yushkevich, P A
and Wolk, D A
- author collaboration
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Aged, 80 and over, Aniline Compounds, Biomarkers, Cognitive Dysfunction/diagnostic imaging, Cross-Sectional Studies, Ethylene Glycols, Female, Hippocampus/diagnostic imaging, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Neurodegenerative Diseases/complications, Neuropsychological Tests
- in
- NeuroImage: Clinical
- volume
- 18
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85041746990
- pmid:29487798
- ISSN
- 2213-1582
- DOI
- 10.1016/j.nicl.2018.02.008
- language
- English
- LU publication?
- no
- id
- ef76976d-9d40-493a-9165-a4aaa210c655
- date added to LUP
- 2024-02-28 14:48:42
- date last changed
- 2025-06-11 05:00:37
@article{ef76976d-9d40-493a-9165-a4aaa210c655,
abstract = {{<p>INTRODUCTION: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneration defined by cross-sectional 'hippocampal volume' only (SNAP/L-) versus both cross-sectional and longitudinal 'hippocampal atrophy rate' (SNAP/L+) and investigate how these definitions impact prevalence and the clinical and biomarker profile of SNAP in Mild Cognitive Impairment (MCI).</p><p>METHODS: 276 MCI patients from ADNI-GO/2 were designated amyloid "positive" (A+) or "negative" (A-) based on their florbetapir scan and neurodegeneration 'positive' or 'negative' based on cross-sectional hippocampal volume and longitudinal hippocampal atrophy rate.</p><p>RESULTS: 74.1% of all SNAP participants defined by the cross-sectional definition of neurodegeneration also met the longitudinal definition of neurodegeneration, whereas 25.9% did not. SNAP/L+ displayed larger white matter hyperintensity volume, a higher conversion rate to dementia over 5 years and a steeper decline on cognitive tasks compared to SNAP/L- and the A- CN group. SNAP/L- had more abnormal values on neuroimaging markers and worse performance on cognitive tasks than the A- CN group, but did not show a difference in dementia conversion rate or longitudinal cognition.</p><p>DISCUSSION: Using a longitudinal definition of neurodegeneration in addition to a cross-sectional one identifies SNAP participants with significant cognitive decline and a worse clinical prognosis for which cerebrovascular disease may be an important driver.</p>}},
author = {{Wisse, L E M and Das, S R and Davatzikos, C and Dickerson, B C and Xie, S X and Yushkevich, P A and Wolk, D A}},
issn = {{2213-1582}},
keywords = {{Aged; Aged, 80 and over; Aniline Compounds; Biomarkers; Cognitive Dysfunction/diagnostic imaging; Cross-Sectional Studies; Ethylene Glycols; Female; Hippocampus/diagnostic imaging; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neurodegenerative Diseases/complications; Neuropsychological Tests}},
language = {{eng}},
pages = {{407--412}},
publisher = {{Elsevier}},
series = {{NeuroImage: Clinical}},
title = {{Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration}},
url = {{http://dx.doi.org/10.1016/j.nicl.2018.02.008}},
doi = {{10.1016/j.nicl.2018.02.008}},
volume = {{18}},
year = {{2018}},
}