SPINART study : validation of the extended magnetic resonance imaging scale for evaluation of joint status in adult patients with severe haemophilia A using baseline data
(2016) In Haemophilia 22(6). p.519-526- Abstract
Introduction: Most previous joint imaging scales for haemophilia have focused on earlier disease stages observed in younger patients. Aim: We sought to demonstrate that the 45-item extended magnetic resonance imaging (eMRI) scale is a valid instrument for measuring joint status in adults with severe haemophilia A. Methods: Six scale categories (effusion/haemarthrosis, synovial hypertrophy, hemosiderin, erosion, subchondral cysts and cartilage loss) in two domains (soft tissue [range = 0–9] and osteochondral [range = 0–36]) were evaluated for each joint. eMRI scores were derived using baseline data from a randomized, controlled, parallel-group clinical trial (SPINART). Quantitative analysis of linearity included assessments of the... (More)
Introduction: Most previous joint imaging scales for haemophilia have focused on earlier disease stages observed in younger patients. Aim: We sought to demonstrate that the 45-item extended magnetic resonance imaging (eMRI) scale is a valid instrument for measuring joint status in adults with severe haemophilia A. Methods: Six scale categories (effusion/haemarthrosis, synovial hypertrophy, hemosiderin, erosion, subchondral cysts and cartilage loss) in two domains (soft tissue [range = 0–9] and osteochondral [range = 0–36]) were evaluated for each joint. eMRI scores were derived using baseline data from a randomized, controlled, parallel-group clinical trial (SPINART). Quantitative analysis of linearity included assessments of the relationship between scores derived from the eMRI scale vs. the 17-point International Prophylaxis Study Group (IPSG) MRI scale and Colorado Adult Joint Assessment Scale (CAJAS). Results: Patient eMRI scores correlated with age (r = 0.58), consistent with the expectation of arthropathy progression and more severe joint changes in older patients. eMRI scores demonstrated excellent between-reader agreement for overall patient score (intraclass correlation coefficient [ICC] = 0.88) and outstanding agreement for knee evaluations (ICC = 0.95). There was a strong linear relationship of the eMRI score with the CAJAS (r = 0.7). Adding individual bone evaluations for each joint increased the sensitivity of the instrument to detect change at low scores. There was minimal ceiling effect (5% maximum scores for all evaluated joints) compared with the IPSG MRI scale (20%). Internal reliability was good (overall Cronbach's alpha = 0.75). Conclusions: Overall, the eMRI scale represents a valid and reliable measure of joint status in adolescents and adults with severe haemophilia A.
(Less)
- author
- Hong, W. ; Raunig, D. and Lundin, B. LU
- organization
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arthropathy, haemophilia, joint, magnetic resonance imaging, rating scale, recombinant factor VIII
- in
- Haemophilia
- volume
- 22
- issue
- 6
- pages
- 519 - 526
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:84995917627
- pmid:27642172
- wos:000388493000004
- ISSN
- 1351-8216
- DOI
- 10.1111/hae.13022
- language
- English
- LU publication?
- yes
- id
- ef85f6f0-6ba3-42c1-a4e6-e96297ec8422
- date added to LUP
- 2016-12-05 12:41:21
- date last changed
- 2024-01-19 14:47:47
@article{ef85f6f0-6ba3-42c1-a4e6-e96297ec8422,
abstract = {{<p>Introduction: Most previous joint imaging scales for haemophilia have focused on earlier disease stages observed in younger patients. Aim: We sought to demonstrate that the 45-item extended magnetic resonance imaging (eMRI) scale is a valid instrument for measuring joint status in adults with severe haemophilia A. Methods: Six scale categories (effusion/haemarthrosis, synovial hypertrophy, hemosiderin, erosion, subchondral cysts and cartilage loss) in two domains (soft tissue [range = 0–9] and osteochondral [range = 0–36]) were evaluated for each joint. eMRI scores were derived using baseline data from a randomized, controlled, parallel-group clinical trial (SPINART). Quantitative analysis of linearity included assessments of the relationship between scores derived from the eMRI scale vs. the 17-point International Prophylaxis Study Group (IPSG) MRI scale and Colorado Adult Joint Assessment Scale (CAJAS). Results: Patient eMRI scores correlated with age (r = 0.58), consistent with the expectation of arthropathy progression and more severe joint changes in older patients. eMRI scores demonstrated excellent between-reader agreement for overall patient score (intraclass correlation coefficient [ICC] = 0.88) and outstanding agreement for knee evaluations (ICC = 0.95). There was a strong linear relationship of the eMRI score with the CAJAS (r = 0.7). Adding individual bone evaluations for each joint increased the sensitivity of the instrument to detect change at low scores. There was minimal ceiling effect (5% maximum scores for all evaluated joints) compared with the IPSG MRI scale (20%). Internal reliability was good (overall Cronbach's alpha = 0.75). Conclusions: Overall, the eMRI scale represents a valid and reliable measure of joint status in adolescents and adults with severe haemophilia A.</p>}},
author = {{Hong, W. and Raunig, D. and Lundin, B.}},
issn = {{1351-8216}},
keywords = {{arthropathy; haemophilia; joint; magnetic resonance imaging; rating scale; recombinant factor VIII}},
language = {{eng}},
month = {{11}},
number = {{6}},
pages = {{519--526}},
publisher = {{Wiley-Blackwell}},
series = {{Haemophilia}},
title = {{SPINART study : validation of the extended magnetic resonance imaging scale for evaluation of joint status in adult patients with severe haemophilia A using baseline data}},
url = {{http://dx.doi.org/10.1111/hae.13022}},
doi = {{10.1111/hae.13022}},
volume = {{22}},
year = {{2016}},
}