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Excess body weight, weight gain and obesity-related cancer risk in women in Norway : the Norwegian Women and Cancer study

da Silva, Marisa LU ; Weiderpass, Elisabete ; Licaj, Idlir ; Lissner, Lauren and Rylander, Charlotta (2018) In British Journal of Cancer 119(5). p.646-656
Abstract

Background: Excess body weight and weight gain have been reported to independently increase the risk of several cancers. There are few published studies in nationally representative populations of women on specific, ‘obesity-related’ cancers in relation to prior weight change and relevant confounders. Methods: Based on self-reported anthropometry, we prospectively assessed body mass index (BMI), weight change over 6 years and subsequent obesity-related cancer risk in the Norwegian Women and Cancer study. We used Cox proportional hazard models to calculate hazard ratios and restricted cubic splines to model potential non-linear dose–response relationships. Results: Excess body weight increased the risk of overall obesity-related cancer,... (More)

Background: Excess body weight and weight gain have been reported to independently increase the risk of several cancers. There are few published studies in nationally representative populations of women on specific, ‘obesity-related’ cancers in relation to prior weight change and relevant confounders. Methods: Based on self-reported anthropometry, we prospectively assessed body mass index (BMI), weight change over 6 years and subsequent obesity-related cancer risk in the Norwegian Women and Cancer study. We used Cox proportional hazard models to calculate hazard ratios and restricted cubic splines to model potential non-linear dose–response relationships. Results: Excess body weight increased the risk of overall obesity-related cancer, postmenopausal breast, colorectal, colon, endometrial and kidney cancer, with endometrial cancer showing a threefold elevated risk. High weight gain (≥ 10 kg) increased the risk of overall obesity-related cancer, postmenopausal breast, endometrial and pancreatic cancer. The association between high weight gain and pancreatic cancer was strong, with 91% increased risk. Conclusions: Maintaining stable weight in middle adulthood, irrespective of BMI category at baseline, and avoiding excess body weight are both important in the prevention of several obesity-related cancers in women. Our finding of increased risk of pancreatic cancer in women with moderate and high weight gain is novel.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
119
issue
5
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:30202086
  • scopus:85053503922
ISSN
0007-0920
DOI
10.1038/s41416-018-0240-5
language
English
LU publication?
no
id
ef8c97a5-9abc-42b3-8982-3f7fda1bc125
date added to LUP
2020-09-10 08:56:34
date last changed
2020-11-24 04:29:35
@article{ef8c97a5-9abc-42b3-8982-3f7fda1bc125,
  abstract     = {<p>Background: Excess body weight and weight gain have been reported to independently increase the risk of several cancers. There are few published studies in nationally representative populations of women on specific, ‘obesity-related’ cancers in relation to prior weight change and relevant confounders. Methods: Based on self-reported anthropometry, we prospectively assessed body mass index (BMI), weight change over 6 years and subsequent obesity-related cancer risk in the Norwegian Women and Cancer study. We used Cox proportional hazard models to calculate hazard ratios and restricted cubic splines to model potential non-linear dose–response relationships. Results: Excess body weight increased the risk of overall obesity-related cancer, postmenopausal breast, colorectal, colon, endometrial and kidney cancer, with endometrial cancer showing a threefold elevated risk. High weight gain (≥ 10 kg) increased the risk of overall obesity-related cancer, postmenopausal breast, endometrial and pancreatic cancer. The association between high weight gain and pancreatic cancer was strong, with 91% increased risk. Conclusions: Maintaining stable weight in middle adulthood, irrespective of BMI category at baseline, and avoiding excess body weight are both important in the prevention of several obesity-related cancers in women. Our finding of increased risk of pancreatic cancer in women with moderate and high weight gain is novel.</p>},
  author       = {da Silva, Marisa and Weiderpass, Elisabete and Licaj, Idlir and Lissner, Lauren and Rylander, Charlotta},
  issn         = {0007-0920},
  language     = {eng},
  month        = {08},
  number       = {5},
  pages        = {646--656},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Excess body weight, weight gain and obesity-related cancer risk in women in Norway : the Norwegian Women and Cancer study},
  url          = {http://dx.doi.org/10.1038/s41416-018-0240-5},
  doi          = {10.1038/s41416-018-0240-5},
  volume       = {119},
  year         = {2018},
}