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Utility of measuring allergen content in house dust samples in a cross-sectional study of respiratory health and atopy in a cohort of immigrant families in poor-quality housing in Malmö, Sweden

Richter, Jens LU (2017) World Immune Regulation Meeting
Abstract
Background. Exposure to allergens plays a role in the development of atopic sensitization and influences allergic phenotype. House dust mites (HDM) are a common source of aeroallergens in many parts of the world. The relationship between indoor environment factors such as temperature, moisture/humidity, and ventilation and HDM allergen load is complex.
Methods. Part of a larger study into the health in its social context of an immigrant population living in poor-quality housing in Malmö, Sweden. Families with small children were identified from health care records (child treated in primary care with respiratory illness), and school records (matched for age range). Families were visited in their homes by health communicators fluent in... (More)
Background. Exposure to allergens plays a role in the development of atopic sensitization and influences allergic phenotype. House dust mites (HDM) are a common source of aeroallergens in many parts of the world. The relationship between indoor environment factors such as temperature, moisture/humidity, and ventilation and HDM allergen load is complex.
Methods. Part of a larger study into the health in its social context of an immigrant population living in poor-quality housing in Malmö, Sweden. Families with small children were identified from health care records (child treated in primary care with respiratory illness), and school records (matched for age range). Families were visited in their homes by health communicators fluent in their language. Family and individual level health data, including skin-prick-tests for a standard panel of aeroallergens, were analyzed together with environmental exposures (mould, dampness, ETS, crowding and allergen content- in the part of the study presented here). Allergen content was analyzed for house dust mite and cockroach allergens: Der pt1, Der f2, and Bla g, from dust samples collected in the affected apartments. Allergen content was measured using sandwich ELISA.
Results. 130 families participated, with usable data for 359 children under the age of 12, 61 older children and 230 parents. The overall exposure to potentially harmful factors was relatively high, the burden of atopy and respiratory diseases was significant. Dust samples were collected in all 130 apartments. Correlations between apartment characteristics , allergen content and health outcomes in this vulnerable population are explored and discussed against the framework of a model explicitly accounting for social determinants of health.
Conclusions. The utility of allergen content measurements in the context of this study was rather limited, as it did not add vital information that could further elucidate pathways and connections between environmental exposures and health outcomes (Less)
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author
organization
publishing date
type
Contribution to conference
publication status
published
subject
conference name
World Immune Regulation Meeting
conference location
Davos, Switzerland
conference dates
2017-03-15 - 2017-03-18
language
English
LU publication?
yes
id
efb1325d-ba3e-4df2-809e-479b1d76550c
date added to LUP
2017-03-21 13:31:00
date last changed
2018-11-21 21:30:51
@misc{efb1325d-ba3e-4df2-809e-479b1d76550c,
  abstract     = {{Background. Exposure to allergens plays a role in the development of atopic sensitization and influences allergic phenotype. House dust mites (HDM) are a common source of aeroallergens in many parts of the world. The relationship between indoor environment factors such as temperature, moisture/humidity, and ventilation and HDM allergen load is complex. <br/>Methods. Part of a larger study into the health in its social context of an immigrant population living in poor-quality housing in Malmö, Sweden. Families with small children were identified from health care records (child treated in primary care with respiratory illness), and school records (matched for age range). Families were visited in their homes by health communicators fluent in their language. Family and individual level health data, including skin-prick-tests for a standard panel of aeroallergens, were analyzed together with environmental exposures (mould, dampness, ETS, crowding and allergen content- in the part of the study presented here). Allergen content was analyzed for house dust mite and cockroach allergens: Der pt1, Der f2, and Bla g, from dust samples collected in the affected apartments. Allergen content was measured using  sandwich ELISA. <br/>Results. 130 families participated, with usable data for 359 children under the age of 12, 61 older children and 230 parents. The overall exposure to potentially harmful factors was relatively high, the burden of atopy and respiratory diseases was significant. Dust samples were collected in all 130 apartments. Correlations between apartment characteristics , allergen content and health outcomes in this vulnerable population are explored and discussed against the framework of a model explicitly accounting for social determinants of health. <br/>Conclusions. The utility of allergen content measurements in the context of this study was rather limited, as it did not add vital information that could further elucidate pathways and connections between environmental exposures and health outcomes}},
  author       = {{Richter, Jens}},
  language     = {{eng}},
  month        = {{03}},
  title        = {{Utility of measuring allergen content in house dust samples in a cross-sectional study of respiratory health and atopy in a cohort of immigrant families in poor-quality housing in Malmö, Sweden}},
  url          = {{https://lup.lub.lu.se/search/files/22884353/JCR_Davos_poster3.pdf}},
  year         = {{2017}},
}