RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5
(2016) In Food and Chemical Toxicology 97. p.110-118- Abstract
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS #... (More)
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
(Less)
- author
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Developmental and reproductive toxicity, Environmental safety, Genotoxicit, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
- in
- Food and Chemical Toxicology
- volume
- 97
- pages
- 110 - 118
- publisher
- Elsevier
- external identifiers
-
- pmid:27475043
- scopus:84997047935
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2016.07.029
- language
- English
- LU publication?
- no
- id
- efb1cc3c-c7b5-4612-b2a3-4a135a2b70c0
- date added to LUP
- 2016-12-12 12:24:41
- date last changed
- 2024-07-12 22:36:44
@article{efb1cc3c-c7b5-4612-b2a3-4a135a2b70c0, abstract = {{<p>The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>}}, author = {{Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Penning, T. M. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.}}, issn = {{0278-6915}}, keywords = {{Developmental and reproductive toxicity; Environmental safety; Genotoxicit; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization}}, language = {{eng}}, month = {{11}}, pages = {{110--118}}, publisher = {{Elsevier}}, series = {{Food and Chemical Toxicology}}, title = {{RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5}}, url = {{http://dx.doi.org/10.1016/j.fct.2016.07.029}}, doi = {{10.1016/j.fct.2016.07.029}}, volume = {{97}}, year = {{2016}}, }