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Intraventricular Hemorrhage and White Matter Injury in Preclinical and Clinical Studies

Romantsik, Olga LU ; Bruschettini, Matteo LU and Ley, David LU (2019) In NeoReviews 20(11). p.636-652
Abstract

Germinal matrix-intraventricular hemorrhage (IVH) occurs in nearly half of infants born at less than 26 weeks' gestation. Up to 50% of survivors with IVH develop cerebral palsy, cognitive deficits, behavioral disorders, posthemorrhagic ventricular dilatation, or a combination of these sequelae. After the initial bleeding and the primary brain injury, inflammation and secondary brain injury might lead to periventricular leukomalacia or diffuse white matter injury. Potential factors that are involved include microglia and astrocyte activation, degradation of blood components with release of "toxic" products, infiltration of the brain by systemic immune cells, death of neuronal and glial cells, and arrest of preoligodendrocyte maturation.... (More)

Germinal matrix-intraventricular hemorrhage (IVH) occurs in nearly half of infants born at less than 26 weeks' gestation. Up to 50% of survivors with IVH develop cerebral palsy, cognitive deficits, behavioral disorders, posthemorrhagic ventricular dilatation, or a combination of these sequelae. After the initial bleeding and the primary brain injury, inflammation and secondary brain injury might lead to periventricular leukomalacia or diffuse white matter injury. Potential factors that are involved include microglia and astrocyte activation, degradation of blood components with release of "toxic" products, infiltration of the brain by systemic immune cells, death of neuronal and glial cells, and arrest of preoligodendrocyte maturation. In addition, impairment of the blood-brain barrier may play a major role in the pathophysiology. A wide range of animal models has been used to explore causes and mechanisms leading to IVH-induced brain injury. Preclinical studies have identified potential targets for enhancing brain repair. However, little has been elucidated about the effectiveness of potential interventions in clinical studies. A systematic review of available preclinical and clinical studies might help identify research gaps and which types of interventions may be prioritized. Future trials should report clinically robust and long-term outcomes after IVH.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeoReviews
volume
20
issue
11
pages
636 - 652
publisher
American Academy of Pediatrics
external identifiers
  • scopus:85074546316
  • pmid:31676738
ISSN
1526-9906
DOI
10.1542/neo.20-11-e636
language
English
LU publication?
yes
id
f00b6fe4-1565-4c06-b43f-d9761ef3b4e5
date added to LUP
2019-11-19 12:50:15
date last changed
2020-01-13 02:31:55
@article{f00b6fe4-1565-4c06-b43f-d9761ef3b4e5,
  abstract     = {<p>Germinal matrix-intraventricular hemorrhage (IVH) occurs in nearly half of infants born at less than 26 weeks' gestation. Up to 50% of survivors with IVH develop cerebral palsy, cognitive deficits, behavioral disorders, posthemorrhagic ventricular dilatation, or a combination of these sequelae. After the initial bleeding and the primary brain injury, inflammation and secondary brain injury might lead to periventricular leukomalacia or diffuse white matter injury. Potential factors that are involved include microglia and astrocyte activation, degradation of blood components with release of "toxic" products, infiltration of the brain by systemic immune cells, death of neuronal and glial cells, and arrest of preoligodendrocyte maturation. In addition, impairment of the blood-brain barrier may play a major role in the pathophysiology. A wide range of animal models has been used to explore causes and mechanisms leading to IVH-induced brain injury. Preclinical studies have identified potential targets for enhancing brain repair. However, little has been elucidated about the effectiveness of potential interventions in clinical studies. A systematic review of available preclinical and clinical studies might help identify research gaps and which types of interventions may be prioritized. Future trials should report clinically robust and long-term outcomes after IVH.</p>},
  author       = {Romantsik, Olga and Bruschettini, Matteo and Ley, David},
  issn         = {1526-9906},
  language     = {eng},
  number       = {11},
  pages        = {636--652},
  publisher    = {American Academy of Pediatrics},
  series       = {NeoReviews},
  title        = {Intraventricular Hemorrhage and White Matter Injury in Preclinical and Clinical Studies},
  url          = {http://dx.doi.org/10.1542/neo.20-11-e636},
  doi          = {10.1542/neo.20-11-e636},
  volume       = {20},
  year         = {2019},
}