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Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease

Rosqvist, Kristina LU ; Odin, Per LU orcid ; Lorenzl, Stefan ; Meissner, Wassilios G. ; Bloem, Bastiaan R. ; Ferreira, Joaquim J. ; Dodel, Richard and Schrag, Anette (2021) In Movement Disorders Clinical Practice 8(4). p.563-570
Abstract

Background: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD). Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision. Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses. Results: Better HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England... (More)

Background: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD). Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision. Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses. Results: Better HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England Scale), less severe disease (Hoehn and Yahr stage), better motor function (Unified PD Rating Scale Part III), and lower non-motor symptoms burden (Non-Motor Symptoms Scale [NMSS]) across all NMSS domains. Having a PDspecialist as physician for PD, contact with a PDnurse, and no hospital admission during the past 3 months were associated with better HRQoL, but having seen a physiotherapist or occupational therapist was associated with worse HRQoL. Conclusions: The results emphasize the importance of optimizing treatment for motor and multiple non-motor symptoms to improve HRQoL in patients with late-stage PD. PD-specific health care resources, particularly PDnurses, are likely important in addressing issues to improve HRQoL in this population. Worse HRQoL in those who had recently seen a physiotherapist or occupational therapist may reflect referral based on factors not measured in this study.

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author
; ; ; ; ; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Parkinsonʼs disease, latestage, health-related quality of life, health care
in
Movement Disorders Clinical Practice
volume
8
issue
4
pages
8 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85102853839
  • pmid:33981789
ISSN
2330-1619
DOI
10.1002/mdc3.13186
language
English
LU publication?
yes
id
f0154ea8-b208-46cb-8029-ce42e4d2b38b
date added to LUP
2021-04-06 09:54:19
date last changed
2024-06-15 09:12:59
@article{f0154ea8-b208-46cb-8029-ce42e4d2b38b,
  abstract     = {{<p>Background: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD). Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision. Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses. Results: Better HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England Scale), less severe disease (Hoehn and Yahr stage), better motor function (Unified PD Rating Scale Part III), and lower non-motor symptoms burden (Non-Motor Symptoms Scale [NMSS]) across all NMSS domains. Having a PDspecialist as physician for PD, contact with a PDnurse, and no hospital admission during the past 3 months were associated with better HRQoL, but having seen a physiotherapist or occupational therapist was associated with worse HRQoL. Conclusions: The results emphasize the importance of optimizing treatment for motor and multiple non-motor symptoms to improve HRQoL in patients with late-stage PD. PD-specific health care resources, particularly PDnurses, are likely important in addressing issues to improve HRQoL in this population. Worse HRQoL in those who had recently seen a physiotherapist or occupational therapist may reflect referral based on factors not measured in this study.</p>}},
  author       = {{Rosqvist, Kristina and Odin, Per and Lorenzl, Stefan and Meissner, Wassilios G. and Bloem, Bastiaan R. and Ferreira, Joaquim J. and Dodel, Richard and Schrag, Anette}},
  issn         = {{2330-1619}},
  keywords     = {{Parkinsonʼs disease, latestage, health-related quality of life, health care}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{4}},
  pages        = {{563--570}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders Clinical Practice}},
  title        = {{Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease}},
  url          = {{http://dx.doi.org/10.1002/mdc3.13186}},
  doi          = {{10.1002/mdc3.13186}},
  volume       = {{8}},
  year         = {{2021}},
}