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Middle-latency auditory evoked potentials during induction of thiopentone anaesthesia in pigs

Martoft, L.; Jensen, E. W.; Jørgensen, P. F.; Forslid, A. LU and Pedersen, H. D. (2001) In Laboratory Animals 35(4). p.353-363
Abstract

A method is described for measuring middle-latency auditory evoked potentials (MLAEP) in consciously awake, non-sedated pigs during the induction of thiopentone anaesthesia (0.6 ml/kg, 2.5% thiopentone solution). It was done by using autoregressive modelling with an exogenous input (ARX). The ability to perceive pain during the induction was compared with (1) the changes in latencies and amplitudes of the MLAEP, (2) the change in a depth of anaesthesia index based on the ARX-model and (3) the change in the 95% spectral edge frequency. The pre-induction MLAEP was easily recordable and looked much like the one in man, dogs and rats. The temporal resolution in the ARX method was sufficiently high to describe the fast changes occurring... (More)

A method is described for measuring middle-latency auditory evoked potentials (MLAEP) in consciously awake, non-sedated pigs during the induction of thiopentone anaesthesia (0.6 ml/kg, 2.5% thiopentone solution). It was done by using autoregressive modelling with an exogenous input (ARX). The ability to perceive pain during the induction was compared with (1) the changes in latencies and amplitudes of the MLAEP, (2) the change in a depth of anaesthesia index based on the ARX-model and (3) the change in the 95% spectral edge frequency. The pre-induction MLAEP was easily recordable and looked much like the one in man, dogs and rats. The temporal resolution in the ARX method was sufficiently high to describe the fast changes occurring during induction of thiopentone anaesthesia. As previously reported from studies in man, dogs and rats, induction of thiopentone anaesthesia resulted in significantly increased latencies and decreased amplitudes of the MLAEP trace as well as in a significantly reduced depth of anaesthesia index and spectral edge frequency. None of the changes, however, related well to the ability to react to a painful stimulus. Whether an ARX-based depth of anaesthesia index designed especially for pigs might be better than the present index (designed for man) for assessing depth of anaesthesia must await the results of further studies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Auditory evoked potentials, Depth of anaesthesia, Induction of anaesthesia, MLAEP, Pig, SEF, Swine, Thiopentone
in
Laboratory Animals
volume
35
issue
4
pages
353 - 363
publisher
Royal Society of Medicine Press
external identifiers
  • scopus:0034809590
ISSN
0023-6772
DOI
10.1258/0023677011911958
language
English
LU publication?
yes
id
f0456bab-bf7a-4a2b-b6c9-42dc94fbb159
date added to LUP
2017-01-26 17:15:16
date last changed
2018-01-07 11:46:57
@article{f0456bab-bf7a-4a2b-b6c9-42dc94fbb159,
  abstract     = {<p>A method is described for measuring middle-latency auditory evoked potentials (MLAEP) in consciously awake, non-sedated pigs during the induction of thiopentone anaesthesia (0.6 ml/kg, 2.5% thiopentone solution). It was done by using autoregressive modelling with an exogenous input (ARX). The ability to perceive pain during the induction was compared with (1) the changes in latencies and amplitudes of the MLAEP, (2) the change in a depth of anaesthesia index based on the ARX-model and (3) the change in the 95% spectral edge frequency. The pre-induction MLAEP was easily recordable and looked much like the one in man, dogs and rats. The temporal resolution in the ARX method was sufficiently high to describe the fast changes occurring during induction of thiopentone anaesthesia. As previously reported from studies in man, dogs and rats, induction of thiopentone anaesthesia resulted in significantly increased latencies and decreased amplitudes of the MLAEP trace as well as in a significantly reduced depth of anaesthesia index and spectral edge frequency. None of the changes, however, related well to the ability to react to a painful stimulus. Whether an ARX-based depth of anaesthesia index designed especially for pigs might be better than the present index (designed for man) for assessing depth of anaesthesia must await the results of further studies.</p>},
  author       = {Martoft, L. and Jensen, E. W. and Jørgensen, P. F. and Forslid, A. and Pedersen, H. D.},
  issn         = {0023-6772},
  keyword      = {Auditory evoked potentials,Depth of anaesthesia,Induction of anaesthesia,MLAEP,Pig,SEF,Swine,Thiopentone},
  language     = {eng},
  number       = {4},
  pages        = {353--363},
  publisher    = {Royal Society of Medicine Press},
  series       = {Laboratory Animals},
  title        = {Middle-latency auditory evoked potentials during induction of thiopentone anaesthesia in pigs},
  url          = {http://dx.doi.org/10.1258/0023677011911958},
  volume       = {35},
  year         = {2001},
}