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Cigarette smoking and the risk of primary Sjögren's syndrome : A nested case control study

Olsson, Peter LU ; Turesson, Carl LU ; Mandl, Thomas LU ; Jacobsson, Lennart LU and Theander, Elke LU (2017) In Arthritis Research and Therapy 19(1).
Abstract

Background: Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren's syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study. Method: Participants in two large population-based health surveys who were later diagnosed with pSS were identified through linkage with the Malmö Sjögren's Syndrome Register. Matched controls were obtained from the health surveys. Results: Sixty-three patients with pSS with pre-diagnostic data from the health surveys were identified. Current... (More)

Background: Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren's syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study. Method: Participants in two large population-based health surveys who were later diagnosed with pSS were identified through linkage with the Malmö Sjögren's Syndrome Register. Matched controls were obtained from the health surveys. Results: Sixty-three patients with pSS with pre-diagnostic data from the health surveys were identified. Current smoking was associated with a significantly lower risk of later being diagnosed with pSS (odds ratio (OR) 0.3; 95% CI 0.1-0.6). Furthermore, former smoking was associated with an increased risk of subsequent pSS diagnosis (OR 4.0; 95% CI 1.8-8.8) compared to never smoking. Similar results were found in a sub-analysis of patients with reported symptom onset after inclusion in the health surveys. Socioeconomic status and levels of formal education had no significant impact on the risk of later being diagnosed with pSS. Conclusion: In this nested case-control study, current smoking was associated with a reduced risk of subsequent diagnosis of pSS. In addition, former smoking was associated with an increased risk. Whether this reflects a biological effect of cigarette smoking or other mechanisms should be further investigated in future studies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Primary Sjögren's syndrome, Risk factor, Smoking, Socio-economy
in
Arthritis Research and Therapy
volume
19
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85014590876
  • wos:000396276000009
ISSN
1478-6354
DOI
10.1186/s13075-017-1255-7
language
English
LU publication?
yes
id
f059cf0d-05a5-40fe-a10a-83346a56f812
date added to LUP
2017-04-10 14:31:38
date last changed
2018-10-07 04:55:03
@article{f059cf0d-05a5-40fe-a10a-83346a56f812,
  abstract     = {<p>Background: Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren's syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study. Method: Participants in two large population-based health surveys who were later diagnosed with pSS were identified through linkage with the Malmö Sjögren's Syndrome Register. Matched controls were obtained from the health surveys. Results: Sixty-three patients with pSS with pre-diagnostic data from the health surveys were identified. Current smoking was associated with a significantly lower risk of later being diagnosed with pSS (odds ratio (OR) 0.3; 95% CI 0.1-0.6). Furthermore, former smoking was associated with an increased risk of subsequent pSS diagnosis (OR 4.0; 95% CI 1.8-8.8) compared to never smoking. Similar results were found in a sub-analysis of patients with reported symptom onset after inclusion in the health surveys. Socioeconomic status and levels of formal education had no significant impact on the risk of later being diagnosed with pSS. Conclusion: In this nested case-control study, current smoking was associated with a reduced risk of subsequent diagnosis of pSS. In addition, former smoking was associated with an increased risk. Whether this reflects a biological effect of cigarette smoking or other mechanisms should be further investigated in future studies.</p>},
  articleno    = {50},
  author       = {Olsson, Peter and Turesson, Carl and Mandl, Thomas and Jacobsson, Lennart and Theander, Elke},
  issn         = {1478-6354},
  keyword      = {Epidemiology,Primary Sjögren's syndrome,Risk factor,Smoking,Socio-economy},
  language     = {eng},
  month        = {03},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Cigarette smoking and the risk of primary Sjögren's syndrome : A nested case control study},
  url          = {http://dx.doi.org/10.1186/s13075-017-1255-7},
  volume       = {19},
  year         = {2017},
}