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Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents

Sarmiento, Luis; Cubas-Dueñas, Ileana LU and Cabrera-Rode, Eduardo (2013) In MEDICC review 15(1). p.29-32
Abstract

A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective... (More)

A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Antibodies, Viral/immunology, Autoantibodies/immunology, Biomedical Research, Child, Cuba, Diabetes Mellitus, Type 1/immunology, Enterovirus/immunology, Humans, Insulin-Secreting Cells/immunology
in
MEDICC review
volume
15
issue
1
pages
4 pages
publisher
MEDICC Medical Education Cooperation with Cuba
external identifiers
  • scopus:84873348115
ISSN
1527-3172
DOI
10.1590/S1555-79602013000100007
language
English
LU publication?
no
id
f06e9c4d-f797-4592-a731-210b0e05648e
date added to LUP
2019-07-08 14:24:54
date last changed
2019-10-23 06:21:04
@article{f06e9c4d-f797-4592-a731-210b0e05648e,
  abstract     = {<p>A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.</p>},
  author       = {Sarmiento, Luis and Cubas-Dueñas, Ileana and Cabrera-Rode, Eduardo},
  issn         = {1527-3172},
  keyword      = {Adolescent,Antibodies, Viral/immunology,Autoantibodies/immunology,Biomedical Research,Child,Cuba,Diabetes Mellitus, Type 1/immunology,Enterovirus/immunology,Humans,Insulin-Secreting Cells/immunology},
  language     = {eng},
  number       = {1},
  pages        = {29--32},
  publisher    = {MEDICC Medical Education Cooperation with Cuba},
  series       = {MEDICC review},
  title        = {Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents},
  url          = {http://dx.doi.org/10.1590/S1555-79602013000100007},
  volume       = {15},
  year         = {2013},
}