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Prevalence of Charles Bonnet syndrome in patients with age-related macular degeneration : systematic review and meta-analysis

Niazi, Siar ; Krogh Nielsen, Marie ; Singh, Amardeep LU ; Sørensen, Torben Lykke and Subhi, Yousif (2020) In Acta Ophthalmologica 98(2). p.121-131
Abstract

Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. A number of patients experience complex lifelike visual experiences—Charles Bonnet syndrome (CBS). In this systematic review, our aim was to provide an overview of the CBS literature in relation to AMD, to determine the prevalence of CBS in patients with AMD and to provide an overview of associated demographical and clinical aspects. We searched the literature databases PubMed/MEDLINE, EMBASE, Web of Science, the Cochrane Central, and PsycINFO on 22 March 2019 for studies evaluating the prevalence of CBS in patients with AMD. Two independent authors extracted the data and evaluated risk of bias. Studies were reviewed... (More)

Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. A number of patients experience complex lifelike visual experiences—Charles Bonnet syndrome (CBS). In this systematic review, our aim was to provide an overview of the CBS literature in relation to AMD, to determine the prevalence of CBS in patients with AMD and to provide an overview of associated demographical and clinical aspects. We searched the literature databases PubMed/MEDLINE, EMBASE, Web of Science, the Cochrane Central, and PsycINFO on 22 March 2019 for studies evaluating the prevalence of CBS in patients with AMD. Two independent authors extracted the data and evaluated risk of bias. Studies were reviewed qualitatively in the text and quantitatively in a meta-analysis including subgroup analyses for differences between demographic and clinical factors. We identified 18 studies with data on >4303 patients with AMD. We found an overall prevalence of CBS of 15.8% (95% confidence interval: 11.0%–21.2%). When looking at consecutively recruited patients with neovascular AMD from the clinic, prevalence of CBS was 7.2% (95% confidence interval: 4.3%–10.6%). Among visitors to visual rehabilitation centres, prevalence of CBS was 31.6% (95% confidence interval: 21.7%–42.3%). Taken together, we find that CBS is rather common in patients with AMD.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
age-related macular degeneration, Charles Bonnet syndrome, prevalence, systematic review, visual hallucinations
in
Acta Ophthalmologica
volume
98
issue
2
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85074568764
  • pmid:31654492
ISSN
1755-375X
DOI
10.1111/aos.14287
language
English
LU publication?
yes
id
f0b2fcfb-8aef-4dc0-a701-c526681c33c8
date added to LUP
2019-11-22 12:28:40
date last changed
2024-06-12 04:25:48
@article{f0b2fcfb-8aef-4dc0-a701-c526681c33c8,
  abstract     = {{<p>Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. A number of patients experience complex lifelike visual experiences—Charles Bonnet syndrome (CBS). In this systematic review, our aim was to provide an overview of the CBS literature in relation to AMD, to determine the prevalence of CBS in patients with AMD and to provide an overview of associated demographical and clinical aspects. We searched the literature databases PubMed/MEDLINE, EMBASE, Web of Science, the Cochrane Central, and PsycINFO on 22 March 2019 for studies evaluating the prevalence of CBS in patients with AMD. Two independent authors extracted the data and evaluated risk of bias. Studies were reviewed qualitatively in the text and quantitatively in a meta-analysis including subgroup analyses for differences between demographic and clinical factors. We identified 18 studies with data on &gt;4303 patients with AMD. We found an overall prevalence of CBS of 15.8% (95% confidence interval: 11.0%–21.2%). When looking at consecutively recruited patients with neovascular AMD from the clinic, prevalence of CBS was 7.2% (95% confidence interval: 4.3%–10.6%). Among visitors to visual rehabilitation centres, prevalence of CBS was 31.6% (95% confidence interval: 21.7%–42.3%). Taken together, we find that CBS is rather common in patients with AMD.</p>}},
  author       = {{Niazi, Siar and Krogh Nielsen, Marie and Singh, Amardeep and Sørensen, Torben Lykke and Subhi, Yousif}},
  issn         = {{1755-375X}},
  keywords     = {{age-related macular degeneration; Charles Bonnet syndrome; prevalence; systematic review; visual hallucinations}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{121--131}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Ophthalmologica}},
  title        = {{Prevalence of Charles Bonnet syndrome in patients with age-related macular degeneration : systematic review and meta-analysis}},
  url          = {{http://dx.doi.org/10.1111/aos.14287}},
  doi          = {{10.1111/aos.14287}},
  volume       = {{98}},
  year         = {{2020}},
}