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IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms

Sterner, Therese LU ; Uldahl, Ada LU ; Svensson, Åke LU ; Borres, Magnus P.; Sjölander, Sigrid; Tunsäter, Alf LU ; Björk, Jonas LU ; Svedman, Cecilia LU ; Bruze, Magnus LU and Von Kobyletzki, Laura LU , et al. (2019) In Clinical and Molecular Allergy 17(1).
Abstract

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%,... (More)

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins. Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.

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published
subject
keywords
Adolescent, Allergen components, Allergy, Asthma
in
Clinical and Molecular Allergy
volume
17
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85063728359
ISSN
1476-7961
DOI
10.1186/s12948-019-0110-6
language
English
LU publication?
yes
id
f0c13555-60e6-48a7-873f-753753dcb74a
date added to LUP
2019-04-23 12:12:33
date last changed
2019-05-14 04:53:50
@article{f0c13555-60e6-48a7-873f-753753dcb74a,
  abstract     = {<p>Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p &lt; 0.001) and eczema (p &lt; 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins. Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.</p>},
  articleno    = {6},
  author       = {Sterner, Therese and Uldahl, Ada and Svensson, Åke and Borres, Magnus P. and Sjölander, Sigrid and Tunsäter, Alf and Björk, Jonas and Svedman, Cecilia and Bruze, Magnus and Von Kobyletzki, Laura and Kiotseridis, Hampus},
  issn         = {1476-7961},
  keyword      = {Adolescent,Allergen components,Allergy,Asthma},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Clinical and Molecular Allergy},
  title        = {IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms},
  url          = {http://dx.doi.org/10.1186/s12948-019-0110-6},
  volume       = {17},
  year         = {2019},
}