Efficient, mild and completely regioselective synthesis of substituted pyridines
(2010) In Chemical Communications 46(19). p.3384-3386- Abstract
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
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https://lup.lub.lu.se/record/f0e01963-249d-407b-9e39-6bdbff4f65f7
- author
- Andersson, Hans ; Sainte-Luce Banchelin, Thomas ; Das, Sajal ; Olsson, Roger LU and Almqvist, Fredrik
- publishing date
- 2010-05-13
- type
- Contribution to journal
- publication status
- published
- in
- Chemical Communications
- volume
- 46
- issue
- 19
- pages
- 3 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:77951983456
- pmid:20428521
- ISSN
- 1359-7345
- DOI
- 10.1039/c000748j
- language
- English
- LU publication?
- no
- id
- f0e01963-249d-407b-9e39-6bdbff4f65f7
- date added to LUP
- 2019-10-02 09:39:21
- date last changed
- 2024-05-29 01:28:44
@article{f0e01963-249d-407b-9e39-6bdbff4f65f7, abstract = {{<p>Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.</p>}}, author = {{Andersson, Hans and Sainte-Luce Banchelin, Thomas and Das, Sajal and Olsson, Roger and Almqvist, Fredrik}}, issn = {{1359-7345}}, language = {{eng}}, month = {{05}}, number = {{19}}, pages = {{3384--3386}}, publisher = {{Royal Society of Chemistry}}, series = {{Chemical Communications}}, title = {{Efficient, mild and completely regioselective synthesis of substituted pyridines}}, url = {{http://dx.doi.org/10.1039/c000748j}}, doi = {{10.1039/c000748j}}, volume = {{46}}, year = {{2010}}, }