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Efficient, mild and completely regioselective synthesis of substituted pyridines

Andersson, Hans ; Sainte-Luce Banchelin, Thomas ; Das, Sajal ; Olsson, Roger LU orcid and Almqvist, Fredrik (2010) In Chemical Communications 46(19). p.3384-3386
Abstract

Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Chemical Communications
volume
46
issue
19
pages
3 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:77951983456
  • pmid:20428521
ISSN
1359-7345
DOI
10.1039/c000748j
language
English
LU publication?
no
id
f0e01963-249d-407b-9e39-6bdbff4f65f7
date added to LUP
2019-10-02 09:39:21
date last changed
2024-05-29 01:28:44
@article{f0e01963-249d-407b-9e39-6bdbff4f65f7,
  abstract     = {{<p>Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.</p>}},
  author       = {{Andersson, Hans and Sainte-Luce Banchelin, Thomas and Das, Sajal and Olsson, Roger and Almqvist, Fredrik}},
  issn         = {{1359-7345}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{19}},
  pages        = {{3384--3386}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Chemical Communications}},
  title        = {{Efficient, mild and completely regioselective synthesis of substituted pyridines}},
  url          = {{http://dx.doi.org/10.1039/c000748j}},
  doi          = {{10.1039/c000748j}},
  volume       = {{46}},
  year         = {{2010}},
}