Tomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation.
(2014) In Nucleosides, Nucleotides & Nucleic Acids 33(4-6). p.287-290- Abstract
- A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. Transduction with toTK1 has been found to efficiently increase the sensitivity of human glioblastoma cells to AZT, and nude rats with intracranial glioblastoma grafts have shown significantly improved survival when treated with the toTK1/AZT system. We show in our paper that the strong suicidal effect of AZT together with toTK1 may be explained by reduced TTP-mediated feedback inhibition of the AZT phosphorylation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4528230
- author
- Larsen, N B ; Munch-Petersen, B and Piskur, Jure LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nucleosides, Nucleotides & Nucleic Acids
- volume
- 33
- issue
- 4-6
- pages
- 287 - 290
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:24940681
- wos:000337939200017
- scopus:84903167594
- pmid:24940681
- ISSN
- 1525-7770
- DOI
- 10.1080/15257770.2013.853781
- language
- English
- LU publication?
- yes
- id
- f111beab-3792-4776-9632-1c170e40a7f4 (old id 4528230)
- date added to LUP
- 2016-04-01 10:39:22
- date last changed
- 2022-02-02 19:48:24
@article{f111beab-3792-4776-9632-1c170e40a7f4, abstract = {{A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. Transduction with toTK1 has been found to efficiently increase the sensitivity of human glioblastoma cells to AZT, and nude rats with intracranial glioblastoma grafts have shown significantly improved survival when treated with the toTK1/AZT system. We show in our paper that the strong suicidal effect of AZT together with toTK1 may be explained by reduced TTP-mediated feedback inhibition of the AZT phosphorylation.}}, author = {{Larsen, N B and Munch-Petersen, B and Piskur, Jure}}, issn = {{1525-7770}}, language = {{eng}}, number = {{4-6}}, pages = {{287--290}}, publisher = {{Taylor & Francis}}, series = {{Nucleosides, Nucleotides & Nucleic Acids}}, title = {{Tomato Thymidine Kinase Is Subject to Inefficient TTP Feedback Regulation.}}, url = {{http://dx.doi.org/10.1080/15257770.2013.853781}}, doi = {{10.1080/15257770.2013.853781}}, volume = {{33}}, year = {{2014}}, }