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Function of an implanted tissue glucose sensor for more than 1 year in animals

Gough, David A; Kumosa, Lucas S LU ; Routh, Timothy L; Lin, Joe T and Lucisano, Joseph Y (2010) In Science Translational Medicine 2(42). p.1-8
Abstract

An implantable sensor capable of long-term monitoring of tissue glucose concentrations by wireless telemetry has been developed for eventual application in people with diabetes. The sensor telemetry system functioned continuously while implanted in subcutaneous tissues of two pigs for a total of 222 and 520 days, respectively, with each animal in both nondiabetic and diabetic states. The sensor detects glucose via an enzyme electrode that is based on differential electrochemical oxygen detection, which reduces the sensitivity of the sensor to encapsulation by the body, variations in local microvascular perfusion, limited availability of tissue oxygen, and inactivation of the enzymes. After an initial 2-week stabilization period, the... (More)

An implantable sensor capable of long-term monitoring of tissue glucose concentrations by wireless telemetry has been developed for eventual application in people with diabetes. The sensor telemetry system functioned continuously while implanted in subcutaneous tissues of two pigs for a total of 222 and 520 days, respectively, with each animal in both nondiabetic and diabetic states. The sensor detects glucose via an enzyme electrode that is based on differential electrochemical oxygen detection, which reduces the sensitivity of the sensor to encapsulation by the body, variations in local microvascular perfusion, limited availability of tissue oxygen, and inactivation of the enzymes. After an initial 2-week stabilization period, the implanted sensors maintained stability of calibration for extended periods. The lag between blood and tissue glucose concentrations was 11.8 +/- 5.7 and 6.5 +/- 13.3 minutes (mean +/- standard deviation), respectively, for rising and falling blood glucose challenges. The lag resulted mainly from glucose mass transfer in the tissues, rather than the intrinsic response of the sensor, and showed no systematic change over implant test periods. These results represent a milestone in the translation of the sensor system to human applications.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Biosensing Techniques, Glucose, Prostheses and Implants, Swine, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
in
Science Translational Medicine
volume
2
issue
42
pages
1 - 8
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • scopus:77955600560
ISSN
1946-6242
DOI
10.1126/scitranslmed.3001148
language
English
LU publication?
no
id
f187db96-8dc3-495f-b3fc-5751ca854349
date added to LUP
2017-06-23 10:46:14
date last changed
2018-06-17 05:24:15
@article{f187db96-8dc3-495f-b3fc-5751ca854349,
  abstract     = {<p>An implantable sensor capable of long-term monitoring of tissue glucose concentrations by wireless telemetry has been developed for eventual application in people with diabetes. The sensor telemetry system functioned continuously while implanted in subcutaneous tissues of two pigs for a total of 222 and 520 days, respectively, with each animal in both nondiabetic and diabetic states. The sensor detects glucose via an enzyme electrode that is based on differential electrochemical oxygen detection, which reduces the sensitivity of the sensor to encapsulation by the body, variations in local microvascular perfusion, limited availability of tissue oxygen, and inactivation of the enzymes. After an initial 2-week stabilization period, the implanted sensors maintained stability of calibration for extended periods. The lag between blood and tissue glucose concentrations was 11.8 +/- 5.7 and 6.5 +/- 13.3 minutes (mean +/- standard deviation), respectively, for rising and falling blood glucose challenges. The lag resulted mainly from glucose mass transfer in the tissues, rather than the intrinsic response of the sensor, and showed no systematic change over implant test periods. These results represent a milestone in the translation of the sensor system to human applications.</p>},
  articleno    = {42ra53},
  author       = {Gough, David A and Kumosa, Lucas S and Routh, Timothy L and Lin, Joe T and Lucisano, Joseph Y},
  issn         = {1946-6242},
  keyword      = {Animals,Biosensing Techniques,Glucose,Prostheses and Implants,Swine,Journal Article,Research Support, N.I.H., Extramural,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {07},
  number       = {42},
  pages        = {1--8},
  publisher    = {American Association for the Advancement of Science (AAAS)},
  series       = {Science Translational Medicine},
  title        = {Function of an implanted tissue glucose sensor for more than 1 year in animals},
  url          = {http://dx.doi.org/10.1126/scitranslmed.3001148},
  volume       = {2},
  year         = {2010},
}