Increased Diameter and Stiffness of Elastic but Not Muscular Arteries in Men with Abdominal Aortic Aneurysm
(2024) In Journal of Applied Physiology- Abstract
It has been proposed that formation of abdominal aortic aneurysm (AAA) is part of a systemic arterial dilatative disease. However, arteries in the upper extremity are scarcely studied and it remains unclear whether both muscular and elastic arteries are affected by the proposed systemic arterial dilatation. The aim of this study was to investigate diameter and stiffness of muscular and elastic arteries in arterial branches originating from the aortic arch. Twenty-six men with AAA (69 ± 4 years) and fifty-seven men without AAA (70 ± 5 years) were included in the study. Ultrasound was used to examine the distal and proximal brachial artery, axillary artery, and common carotid artery (CCA), and measurement of diameter and diameter change... (More)
It has been proposed that formation of abdominal aortic aneurysm (AAA) is part of a systemic arterial dilatative disease. However, arteries in the upper extremity are scarcely studied and it remains unclear whether both muscular and elastic arteries are affected by the proposed systemic arterial dilatation. The aim of this study was to investigate diameter and stiffness of muscular and elastic arteries in arterial branches originating from the aortic arch. Twenty-six men with AAA (69 ± 4 years) and fifty-seven men without AAA (70 ± 5 years) were included in the study. Ultrasound was used to examine the distal and proximal brachial artery, axillary artery, and common carotid artery (CCA), and measurement of diameter and diameter change were performed with wall-tracking software. Blood pressure measurements were used to calculate local arterial wall stiffness indices. The AAA cohort presented larger arterial diameters in the CCA and axillary artery after adjustment for body surface area (
(Less)
p=0.002, respectively), while the brachial artery diameters were unchanged. Indices of increased stiffness in CCA (e.g., lower distensibility,
p=0.003) were seen in subjects with AAA, after adjustments for body mass index and mean arterial blood pressure. This study supports the theory of a systemic arterial dilating diathesis in in peripheral elastic, but not in muscular, arteries. Peripheral elastic arteries also exhibited increased stiffness, in analogy with findings in the aorta in AAA.
- author
- Shlimon, Kristian ; Lindenberger, Marcus ; De Basso, Rachel ; Cinthio, Magnus LU and Bjarnegård, Niclas
- organization
- publishing date
- 2024-04-25
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Journal of Applied Physiology
- publisher
- American Physiological Society
- external identifiers
-
- pmid:38660725
- ISSN
- 1522-1601
- DOI
- 10.1152/japplphysiol.00875.2023
- language
- English
- LU publication?
- yes
- id
- f195455a-3c8b-4d99-a042-ecdf0fbd41ce
- date added to LUP
- 2024-06-04 09:57:31
- date last changed
- 2024-06-05 11:49:44
@article{f195455a-3c8b-4d99-a042-ecdf0fbd41ce,
abstract = {{<p>It has been proposed that formation of abdominal aortic aneurysm (AAA) is part of a systemic arterial dilatative disease. However, arteries in the upper extremity are scarcely studied and it remains unclear whether both muscular and elastic arteries are affected by the proposed systemic arterial dilatation. The aim of this study was to investigate diameter and stiffness of muscular and elastic arteries in arterial branches originating from the aortic arch. Twenty-six men with AAA (69 ± 4 years) and fifty-seven men without AAA (70 ± 5 years) were included in the study. Ultrasound was used to examine the distal and proximal brachial artery, axillary artery, and common carotid artery (CCA), and measurement of diameter and diameter change were performed with wall-tracking software. Blood pressure measurements were used to calculate local arterial wall stiffness indices. The AAA cohort presented larger arterial diameters in the CCA and axillary artery after adjustment for body surface area (<br>
p=0.002, respectively), while the brachial artery diameters were unchanged. Indices of increased stiffness in CCA (e.g., lower distensibility, <br>
p=0.003) were seen in subjects with AAA, after adjustments for body mass index and mean arterial blood pressure. This study supports the theory of a systemic arterial dilating diathesis in in peripheral elastic, but not in muscular, arteries. Peripheral elastic arteries also exhibited increased stiffness, in analogy with findings in the aorta in AAA.<br>
</p>}},
author = {{Shlimon, Kristian and Lindenberger, Marcus and De Basso, Rachel and Cinthio, Magnus and Bjarnegård, Niclas}},
issn = {{1522-1601}},
language = {{eng}},
month = {{04}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Increased Diameter and Stiffness of Elastic but Not Muscular Arteries in Men with Abdominal Aortic Aneurysm}},
url = {{http://dx.doi.org/10.1152/japplphysiol.00875.2023}},
doi = {{10.1152/japplphysiol.00875.2023}},
year = {{2024}},
}